New Microbes New Infect . Clinical characteristics and short-term mortality of 102 hospitalized hemodialysis patients infected with SARS-CoV-2 omicron BA.2.2.1 variant in Shanghai, China

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New Microbes New Infect


. 2022 Nov 25;101058.
doi: 10.1016/j.nmni.2022.101058. Online ahead of print.
Clinical characteristics and short-term mortality of 102 hospitalized hemodialysis patients infected with SARS-CoV-2 omicron BA.2.2.1 variant in Shanghai, China


Wen Jing Bao ¹ , Shun Kun Fu ¹ , Hua Zhang ¹ , Jun Li Zhao ² , Hui Min Jin ¹ , Xiu Hong Yang ¹



Affiliations

• PMID: 36447944
• PMCID: PMC9691279
• DOI: 10.1016/j.nmni.2022.101058

Abstract

Background: The aim of this study was to analyze clinical features and short-term mortality in hemodialysis (HD) patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) omicron BA.2.2.1 variant.
Methods: In a retrospective single-center case series, 102 consecutive hospitalized HD patients infected with the coronavirus omicron variant were assessed at Pudong Hospital in Shanghai, China, from April 6 to April 18, 2022; the final date of follow-up was May 16, 2022. Clinical, laboratory, chest CT, and treatment data were collected and analyzed. The association between these factors and all-cause mortality was studied using univariate and multivariate analyses. The relationship between lymphocyte count and short-term mortality was based on receiver operating characteristic (ROC) curve analysis. Kaplan-Meier analysis was used to assess overall survival.
Results: In total, 102 patients were included in this study. The patients were divided into two groups: HD patients with pneumonia (N = 46) and without pneumonia (N = 56). Of the 102 patients, 12 (11.8%) died. Multivariate regression analysis revealed that all-cause mortality was correlated with lymphocyte counts and type B natriuretic peptide (BNP), C-reactive protein (CRP), and D-dimer levels (P < 0.05). The cut-off value of lymphocyte counts was 0.61 × 10⁹/L for all-cause mortality. The overall survival rate was significantly different between HD patients with and without pneumonia (P < 0.05).
Conclusions: Lymphocyte counts are important for the prediction of short-term mortality in HD patients with SARS-CoV-2 infection. HD patients with lung involvement have poorer survival rates than those without lung involvement.

Keywords: All-cause mortality; hemodialysis (HD); lymphocyte; severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).