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Transl Med UniSa
. 2022 Aug 29;24(2):1-11.
doi: 10.37825/2239-9754.1034. eCollection 2022.
Acute Coronary Syndrome in Patients with SARS-CoV-2 Infection: Pathophysiology and Translational Perspectives
Francesco P Cancro 1 , Michele Bellino 1 , Luca Esposito 1 , Stefano Romei 1 , Mario Centore 1 , Debora D'Elia 1 , Mario Cristiano 1 , Angelantonio Maglio 1 , Albino Carrizzo 1 2 , Barbara Rasile 1 , Carmine Alfano 1 , Carmine Vecchione 1 2 , Gennaro Galasso 1
Affiliations
- PMID: 36447945
- PMCID: PMC9673986
- DOI: 10.37825/2239-9754.1034
Abstract
Acute coronary syndromes (ACS) may complicate the clinical course of patients with Coronavirus Disease 2019 (COVID-19). It is still unclear whether this condition is a direct consequence of the primary disease. However, several mechanisms including direct cellular damage, endothelial dysfunction, in-situ thrombosis, systemic inflammatory response, and oxygen supply-demand imbalance have been described in patients with COVID-19. The onset of a prothrombotic state may also be facilitated by the endothelial dysfunction secondary to the systemic inflammatory response and to the direct viral cell damage. Moreover, dysfunctional endothelial cells may enhance vasospasm and platelet aggregation. The combination of these factors promotes atherosclerotic plaque instability, thrombosis and, consequently, type 1 myocardial infarction. Furthermore, severe hypoxia due to extensive pulmonary involvement, in association with other conditions described in COVID-19 such as sepsis, tachyarrhythmias, anemia, hypotension, and shock, may lead to mismatch between oxygen supply and demand, and cause type 2 myocardial infarction. A deeper understanding of the potential pathophysiological mechanisms underlying ACS in patients with COVID-19 could help the therapeutic management of these very high-risk patients.
Keywords: Acute coronary syndromes; COVID-19; Coronary artery disease; Endothelial dysfunction; Myocardial infarction; Novel coronavirus 2019; Oxidative stress; SARS-CoV-2.