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Pediatr Neurol . SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke

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  • Pediatr Neurol . SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke


    Pediatr Neurol


    . 2022 Nov 11;S0887-8994(22)00210-7.
    doi: 10.1016/j.pediatrneurol.2022.10.003. Online ahead of print.
    SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke


    MaryGlen J Vielleux 1 , Shanna Swartwood 1 , Dan Nguyen 2 , Karen E James 3 , Bree Barbeau 4 , Joshua L Bonkowsky 5



    Affiliations

    Abstract

    Background: There is an increased risk of stroke in adults with severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) infection, but whether there is a similar association with stroke in children is unclear. Our objective was to determine whether there is a correlation between COVID-19 infection, multisystem inflammatory syndrome in children (MIS-C), and pediatric ischemic stroke.
    Methods: This was a retrospective, population-based cohort analysis between March 1, 2020, and June 30, 2021, conducted at a children's hospital. Pediatric patients with a diagnosis of ischemic stroke were identified using ICD-10 diagnoses of ischemic stroke, cerebrovascular accident, or cerebral infarction.
    Results: We identified 16 patients, seven male and nine female, with ischemic stroke. Ages were 8 months to 17 years (median 11.5 years). More Asian (6%) and black (13%) patients had strokes compared with population prevalence (2% each, respectively). No patients had active COVID-19 infection. COVID-19 antibodies were identified in five of 11 patients tested (45%), of whom three were diagnosed with MIS-C. 82% of the strokes occurred between February and May 2021. The peak incidence was in February 2021, which was two months after peak incidence of pediatric cases of COVID-19 and one month after the peak of MIS-C cases.
    Conclusions: Our study suggests that prior COVID-19 infection, but not acute infection, is correlated with a risk for stroke in the pediatric population. The risk for stroke appears to be distinct from the risk for MIS-C.

    Keywords: COVID-19; Coronavirus; Ischemic; MIS-C; Pediatric; Stroke.

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