Cureus . Sequential Organ Failure Assessment (SOFA) Score and Mortality Prediction in Patients With Severe Respiratory Distress Secondary to COVID-19

[tetano]

Cureus


. 2022 Jul 16;14(7):e26911.
doi: 10.7759/cureus.26911. eCollection 2022 Jul.
Sequential Organ Failure Assessment (SOFA) Score and Mortality Prediction in Patients With Severe Respiratory Distress Secondary to COVID-19


Mohamed Fayed ¹ , Nimesh Patel ² , Santhalakshmi Angappan ¹ , Katherine Nowak ³ , Felipe Vasconcelos Torres ⁴ , Donald H Penning ⁵ , Anoop K Chhina ⁶



Affiliations

• PMID: 35865183
• PMCID: PMC9290429
• DOI: 10.7759/cureus.26911

Abstract

Background This study looks at the validity of the sequential organ failure assessment score (SOFA) in detecting mortality in patients with Coronavirus disease of 2019 (COVID-19) pneumonia. Also, it is looking to determine the optimal SOFA score that will discriminate between mortality and survival. Methods It is a retrospective chart review of the patients admitted to Henry Ford Hospital from March 2020 to December 2020 with COVID-19 pneumonia who developed severe respiratory distress. We collected the following information; patient demographics (age, sex, body mass index), co-morbidities (history of diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease, coronary artery disease, or cancer), SOFA scores (the ratio of arterial oxygen tension (PaO₂) to the fraction of inspired oxygen, Glasgow Coma Scale (GCS) score, mean arterial pressure, serum creatinine level, bilirubin level, and platelet count) as well as inpatient mortality. Results There were 320 patients; out of these, 111 were intubated. The receiver operating characteristic (ROC) curve for SOFA at the moment of inclusion in the study had an area under the curve of 0.883. The optimal point for discrimination between mortality and survival is SOFA of 5. A SOFA score of less than two is associated with 100% survival, while a score of more than 11 is associated with 100% mortality. Conclusions SOFA score in COVID-19 patients with severe respiratory distress strongly correlates with the initial SOFA score. It is a valuable tool for predicting mortality in COVID-19 patients.

Keywords: covid 19; health care outcomes; invasive mechanical ventilation; predicted mortality; prognostic modelling; receiver operating characteristic (roc) analysis; resource allocation; resource-limited setting; severe respiratory failure; sofa score.