J Intern Med . Early SARS-CoV-2 associated acute transverse myelitis: A case for neurotropism?

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J Intern Med


. 2022 Jul 4.
doi: 10.1111/joim.13542. Online ahead of print.
Early SARS-CoV-2 associated acute transverse myelitis: A case for neurotropism?


Irene F Lu ¹ , Jack S Cornish ¹ , Aadith Ashok ¹ , Siew Kar Chen ¹ , Eugene Athan ^{1 2} , Andrew Hughes ¹



Affiliations

• PMID: 35781711
• DOI: 10.1111/joim.13542

Abstract

There are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of Severe-Acute-Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology three days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and Remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2 associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of Remdesivir in the therapeutic regimen. This article is protected by copyright. All rights reserved.

Keywords: COVID-19; SARS-COV-2; myelitis; neurotropism.