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Sci Rep . Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19

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  • Sci Rep . Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19


    Sci Rep


    . 2022 May 13;12(1):7977.
    doi: 10.1038/s41598-022-11929-8.
    Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19


    Kapil Nanwani-Nanwani 1 , Lorenzo López-Pérez 2 , Carola Giménez-Esparza 3 , Inés Ruiz-Barranco 1 , Elena Carrillo 1 , María Soledad Arellano 1 , Domingo Díaz-Díaz 2 , Beatriz Hurtado 3 , Andoni García-Muñoz 1 , María Ángeles Relucio 3 , Manuel Quintana-Díaz 1 4 5 , María Rosario Úrbez 6 , Andrés Saravia 1 , María Victoria Bonan 7 , Francisco García-Río 4 8 9 , María Luisa Testillano 10 , Jesús Villar 9 11 12 , Abelardo García de Lorenzo 1 4 5 , José Manuel Añón 13 14 15



    AffiliationsFree article

    Abstract

    Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68-121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8-31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population.


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