Cancers (Basel) . Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)

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Cancers (Basel)


. 2022 Apr 27;14(9):2191.
doi: 10.3390/cancers14092191.
Outcome and Prognostic Factors of COVID-19 Infection in Swiss Cancer Patients: Final Results of SAKK 80/20 (CaSA)


Markus Joerger ¹ , Yannis Metaxas ² , Khalil Zaman ³ , Olivier Michielin ⁴ , Nicolas Mach ⁵ , Adrienne Bettini ⁶ , Andreas M Schmitt ⁷ , Nathan Cantoni ⁸ , Clemens B Caspar ⁹ , Sonja Stettler ¹⁰ , Roma Malval ¹¹ , Miklos Pless ¹² , Christian Britschgi ¹³ , Christoph Renner ¹⁴ , Dieter Koeberle ¹⁵ , Jessica D Schulz ¹⁶ , Christoph Kopp ¹⁶ , Stefanie Hayoz ¹⁶ , Anastasios Stathis ¹⁷ , Roger von Moos ¹⁸ , Swiss Group for Clinical Cancer Research (SAKK)



Affiliations

• PMID: 35565320
• DOI: 10.3390/cancers14092191

Free article

Abstract

Purpose: These are the final results of a national registry on cancer patients with COVID-19 in Switzerland.
Methods: We collected data on symptomatic COVID-19-infected cancer patients from 23 Swiss sites over a one-year period starting on 1 March 2020. The main objective was to assess the outcome (i.e., mortality, rate of hospitalization, ICU admission) of COVID-19 infection in cancer patients; the main secondary objective was to define prognostic factors.
Results: From 455 patients included, 205 patients (45%) had non-curative disease, 241 patients (53%) were hospitalized for COVID-19, 213 (47%) required oxygen, 43 (9%) invasive ventilation and 62 (14%) were admitted to the ICU. Death from COVID-19 infection occurred in 98 patients, resulting in a mortality rate of 21.5%. Age ≥65 years versus <65 years (OR 3.14, p = 0.003), non-curative versus curative disease (OR 2.42, p = 0.012), ICU admission (OR 4.45, p < 0.001) and oxygen requirement (OR 20.28, p < 0.001) were independently associated with increased mortality.
Conclusions: We confirmed high COVID-19 severity and mortality in real-world cancer patients during the first and second wave of the pandemic in a country with a decentralized, high-quality, universal-access health care system. COVID-19-associated mortality was particularly high for those of older age in a non-curative disease setting, requiring oxygen or ICU care.

Keywords: COVID-19; cancer; cancer treatment; coronavirus; pandemic.