J Pediatr Hematol Oncol . Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C

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J Pediatr Hematol Oncol


. 2022 Apr 1;44(3):e812-e815.
doi: 10.1097/MPH.0000000000002370.
Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C


Eman T Al-Antary ¹ , Rewa Arar ¹ , Yogindra Persaud ¹ , Basil M Fathalla ² , Madhvi Rajpurkar ¹ , Kanta Bhambhani ¹



Affiliations

• PMID: 35319513
• DOI: 10.1097/MPH.0000000000002370

Abstract

The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.