Transplantation
. 2022 Mar 21.
doi: 10.1097/TP.0000000000004075. Online ahead of print.
Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Mo After a Diagnosis of COVID-19
Raphaël Duivenvoorden 1 , Priya Vart, Marlies Noordzij, Augusto C Soares Dos Santos , Jr, Alex B Zulkarnaev, Casper F M Franssen, Dirk Kuypers, Erol Demir, Hormat Rahimzadeh, Julia Kerschbaum, Kitty J Jager, Kultigin Turkmen, Marc H Hemmelder, Marcel Schouten, María Luisa Rodríguez-Ferrero, Marta Crespo, Ron T Gansevoort, Luuk B Hilbrands, Jeroen B van der Net, Marie Essig, Peggy W G du Buf-Vereijken, Betty van Ginneken, Nanda Maas, Liffert Vogt, Brigit C van Jaarsveld, Frederike J Bemelman, Farah Klingenberg-Salahova, Frederiek Heenan-Vos, Marc G Vervloet, Azam Nurmohamed, Daniel Abramowicz, Sabine Verhofstede, Omar Maoujoud, Thomas Malfait, Jana Fialova, Edoardo Melilli, Alexandre Favà, Josep M Cruzado, Nuria Montero Perez, Joy Lips, Harmen Krepel, Harun Adilovic, Maaike Hengst, Constantijn Konings, Andrzej Rydzewski, Philippe Braconnier, Daniel Weis, Ryszard Gellert, João Oliveira, Daniela G Alferes, Daniela Radulescu, Elena V Zakharova, Patrice Max Ambuehl, Rebecca Guidotti, Andrea Walker, Fanny Lepeytre, Clémentine Rabaté, Guy Rostoker, Sofia Marques, Tijana Azasevac, Gordana Strazmester Majstorovic, Dajana Katicic, Marc Ten Dam, Thilo Krüger, Szymon Brzosko, Vassilios Liakopoulos, Adriaan L Zanen, Susan J J Logtenberg, Lutz Fricke, Olexandr Kuryata, Jeroen J P Slebe, Samar Abd ElHafeez, Delphine Kemlin, Jacqueline van de Wetering, Marlies E J Reinders, Dennis A Hesselink, J Kal-van Gestel, Jaromir Eiselt, Lukas Kielberger, Hala S El-Wakil, Martine Verhoeven, Ian Logan, Cristina Canal, Carme Facundo, Ana M Ramos, Alicja Debska-Slizien, Nicoline M H Veldhuizen, Eirini Tigka, Maria Anna Polyzou Konsta, Stylianos Panagoutsos, Francesca Mallamaci, Adele Postorino, Francesco Cambareri, Irina Matceac, Ionut Nistor, Adrian Covic, J H M Groeneveld, Jolanda Jousma, Marjolijn van Buren, Fritz Diekmann, Federico Oppenheimer, Miquel Blasco, Tiago Assis Pereira, Carlos Arias-Cabrales, Laura Llinàs-Mallol, Anna Buxeda, Carla Burballa Tàrrega, Dolores Redondo-Pachon, Maria Dolores Arenas Jimenez, Alberto Mendoza-Valderrey, Ana Cristina Martins, Catarina Mateus, Goncalo Alvila, Ivo Laranjinha, Julia M Hofstra, Machiel A Siezenga, Antonio Franco, David Arroyo, Sandra Castellano, Sagrario Balda Manzanos, R Haridian Sosa Barrios, Wim Lemahieu, Karlijn Bartelet, Ahmet Burak Dirim, Mehmet Sukru Sever, Aydin Turkmen, Seda Şafak, Daan A M J Hollander, Stefan Büttner, Aiko P J de Vries, Soufian Meziyerh, Danny van der Helm, Marko Mallat, Hanneke Bouwsma, Sivakumar Sridharan, Kristina Petruliene, Sharon-Rose Maloney, Iris Verberk, Frank M van der Sande, Maarten H L Christiaans, N Mohan Kumar, Marina Di Luca, Serhan Z Tuğlular, Andrea Kramer, Charles Beerenhout, Peter T Luik, Martin Tiefenthaler, Bruno Watschinger, Aaltje Y Adema, Vadim A Stepanov, Ilaria Gandolfini, Umberto Maggiore, Anselm Fliedner, Anders Åsberg, Geir Mjoen, Hitoshi Miyasato, Carola W H de Fijter, Nicola Mongera, Stefano Pini, Consuelo de Biase, Angele Kerckhoffs, Anne Els van de Logt, Rutger Maas, Olga Lebedeva, Veronica Lopez, Louis J M Reichert, Jacobien Verhave, Denis Titov, Ekaterina V Parshina, Luca Zanoli, Carmelita Marcantoni, Gijs van Kempen, Liesbeth E A van Gils-Verrij, John C Harty, Marleen Meurs, Marek Myslak, Yuri Battaglia, Paolo Lentini, Edwin den Deurwaarder, Maria Stendahl, Ivan Rychlik, Carlos J Cabezas-Reina, Ana Maria Roca, Ferdau Nauta, İdris Sahin, Eric Goffin, Nada Kanaan, Laura Labriola, Arnaud Devresse, Anabel Diaz-Mareque, Armando Coca, Gabriel de Arriba, Björn K I Meijers, Maarten Naesens, Bruno Desschans, Annelies Tonnerlier, Karl M Wissing, Ivana Dedinska, Giuseppina Pessolano, Shafi Malik, Evangelia Dounousi, Evangelos Papachristou, Stefan P Berger, Esther Meijer, Jan Stephan F Sanders, Akin Özyilmaz, Jadranka Buturović Ponikvar, Andreja Marn Pernat, Damjan Kovac, Miha Arnol, Robert Ekart, Alferso C Abrahams, Femke M Molenaar, Arjan D van Zuilen, Sabine C A Meijvis, Helma Dolmans, Ekamol Tantisattamo, Pasquale Esposito, Jean-Marie Krzesinski, Jean Damacène Barahira, Maurizio Gallieni, Paloma Leticia Martin-Moreno, Gabriele Guglielmetti, Gabriella Guzzo, Nestor Toapanta, Maria Jose Soler, Antinus J Luik, Willi H M van Kuijk, Lonneke W H Stikkelbroeck, Marc M H Hermans, Laurynas Rimsevicius, Marco Righetti, Mahmud Islam, Nicole Heitink-Ter Braak, ERACODA Collaborators
Affiliations
- PMID: 35320154
- DOI: 10.1097/TP.0000000000004075
Abstract
Background: Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)-related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in patients who survive COVID-19.
Methods: We analyzed data from adult kidney transplant patients in the European Renal Association COVID-19 Database who presented with COVID-19 between February 1, 2020, and January 31, 2021.
Results: We included 912 patients with a mean age of 56.7 (±13.7) y. 26.4% were not hospitalized, 57.5% were hospitalized without need for intensive care unit (ICU) admission, and 16.1% were hospitalized and admitted to the ICU. At 3 mo follow-up survival was 82.3% overall, and 98.8%, 84.2%, and 49.0%, respectively, in each group. At 3 mo follow-up biopsy-proven acute rejection, need for renal replacement therapy, and graft failure occurred in the overall group in 0.8%, 2.6%, and 1.8% respectively, and in 2.1%, 10.6%, and 10.6% of ICU-admitted patients, respectively. Of the surviving patients, 83.3% and 94.4% reached their pre-COVID-19 physician-reported functional and mental health status, respectively, within 3 mo. Of patients who had not yet reached their prior functional and mental health status, their treating physicians expected that 79.6% and 80.0%, respectively, still would do so within the coming year. ICU admission was independently associated with a low likelihood to reach prior functional and mental health status.
Conclusions: In kidney transplant recipients alive at 3-mo follow-up, clinical, physician-reported functional, and mental health recovery was good for both nonhospitalized and hospitalized patients. Recovery was, however, less favorable for patients who had been admitted to the ICU.