Am Heart J Plus . COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil

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Am Heart J Plus


. 2021 Dec;12:100069.
doi: 10.1016/j.ahjo.2021.100069. Epub 2021 Nov 20.
COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil


Mariah Rodrigues Paulino ¹ , José Alfredo de Sousa Moreira ¹ , Marcelo Goulart Correia ¹ , Léo Rodrigo Abrahão Dos Santos ² , Ingrid Paiva Duarte ² , Letícia Roberto Sabioni ¹ , Fabiana Bergamin Mucillo ¹ , Rafael Quaresma Garrido ¹ , Stephan Lachtermacher Pacheco ¹ , Andrea de Lorenzo ^{1 3} , Cristiane da Cruz Lamas ^{1 2 4}



Affiliations

• PMID: 34841378
• PMCID: PMC8604803
• DOI: 10.1016/j.ahjo.2021.100069

Abstract

Background: Cardiovascular disease is associated with severe COVID-19. Our aim was to describe clinical and laboratory features (including electrocardiographic and echocardiographic ones) and outcomes of patients with cardiac disease hospitalized with COVID-19.
Methods: This is an observational retrospective study of consecutive adult patients admitted, between March and September of 2020, with confirmed SARSCoV-2 infection. Data were collected as per the ISARIC case report form and complemented with variables related to heart disease.
Results: One hundred twenty-one patients were included. Mean age was 60 SD 15.2 years and 80/121(66.1%) were male. Two-thirds of the patients (80/121, 66.1%) had COVID-19 at the time of hospital admission and COVID-19 was the reason for hospitalization in 42 (34.7%). Other reasons for hospital admission were acute coronary syndrome (26%) and decompensated heart failure (14.8%). Chronic cardiac diseases were found in 106/121 (87.6%), mostly coronary artery disease (62%) or valve disease (33.9%). A transthoracic echocardiogram was performed in 93/121(76.8%) and enlarged cardiac chambers were found in 71% (66/93); admission ECG was done in 93 cases (93/121, 76.8%), and 89.2% (83/93) were abnormal. Hospital-acquisition of COVID-19 occurred in 20 (16.5%) of patients and their mortality was 50%. On bivariate analysis for mortality, BNP levels and troponin levels were NOT associated with mortality. On multivariate analysis, only C reactive protein levels and creatinine levels were significant.
Conclusions: COVID-19 impacted the profile of hospital admissions in cardiac patients. BNP and troponin levels were not associated with mortality and may not be good prognostic discriminators in cardiac patients.

Keywords: COVID-19; Cardiac disease; Cardiac surgery; Coronavirus; Hospitalization; Mortality.