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Emerg Infect Dis
. 2021 Sep 29;27(11).
doi: 10.3201/eid2711.211612. Online ahead of print.
Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination
Heather N Grome, Michael Threlkeld, Steve Threlkeld, Charles Newman, Roosecelis Brasil Martines, Sarah Reagan-Steiner, Michael A Whitt, Maria Gomes-Solecki, Nisha Nair, Mary-Margaret Fill, Timothy F Jones, William Schaffner, John Dunn
- PMID: 34586059
- DOI: 10.3201/eid2711.211612
Abstract
We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology of this syndrome, regardless of vaccination status, remains poorly understood.
Keywords: COVID-19; MIS-A; SARS-CoV-2; coronavirus disease; multisystem inflammatory syndrome in adults; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; vaccines; viruses.