Circ J


. 2021 Sep 22.
doi: 10.1253/circj.CJ-21-0684. Online ahead of print.
Multiple Cardiovascular Diseases or Risk Factors Increase the Severity of Coronavirus Disease 2019


Tomoyuki Yamada 1 2 , Taku Ogawa 1 3 , Kenta Minami 1 , Yusuke Kusaka 1 4 , Masaaki Hoshiga 5 , Akira Ukimura 1 5 , Takahide Sano 6 , Takeshi Kitai 7 , Taishi Yonetsu 8 , Sho Torii 9 , Shun Kohsaka 10 , Shunsuke Kuroda 11 , Koichi Node 12 , Yuya Matsue 13 14 , Shingo Matsumoto 15



Affiliations

Abstract

Background: This study aimed to determine whether disease severity varied according to whether coronavirus disease 2019 (COVID-19) patients had multiple or single cardiovascular diseases and risk factors (CVDRFs).Methods and Results:COVID-19 patients with single (n=281) or multiple (n=412) CVDRFs were included retrospectively. Multivariable logistic regression showed no significant difference in the risk of in-hospital death between groups, but patients with multiple CVDRFs had a significantly higher risk of acute respiratory distress syndrome (odds ratio: 1.75, 95% confidence interval: 1.09-2.81).
Conclusions: COVID-19 patients with multiple CVDRFs have a higher risk of complications than those with a single CDVRF.

Keywords: Cardiovascular disease; Cardiovascular risk factors; Coronavirus disease.