Rev Esp Patol . Multi-organ pathological findings associated with COVID-19 in postmortem needle core biopsies in four patients and a review of the current literature

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Rev Esp Patol


. Oct-Dec 2021;54(4):275-280.
doi: 10.1016/j.patol.2020.09.003. Epub 2020 Oct 5.
Multi-organ pathological findings associated with COVID-19 in postmortem needle core biopsies in four patients and a review of the current literature


Tais González Pessolani ¹ , Marta Muñóz Fernández de Legaria ² , Margarita Elices Apellániz ² , Silvia Salinas Moreno ² , María Del Mar Lorido Cortés ² , Sagrario García Sánchez ²



Affiliations

• PMID: 34544557
• DOI: 10.1016/j.patol.2020.09.003

Abstract

Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality. Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic. Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae.

Keywords: COVID-19; Coronavirus; Histopathology; Microscopy; Microscopía; Neumonía; Pathogenesis; Patogénesis; Patología; Pneumonia.