Int J Infect Dis . Day by day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalised health-care workers: a 90-day follow-up study

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Int J Infect Dis


. 2021 May 19;S1201-9712(21)00434-3.
doi: 10.1016/j.ijid.2021.05.032. Online ahead of print.
Day by day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalised health-care workers: a 90-day follow-up study


Kent J Nielsen ¹ , Jesper Medom Vestergaard ² , Vivi Schl?nssen ³ , Jens Peter Bonde ⁴ , Kathrine Agerg?rd Kaspersen ⁵ , Karin Biering ¹ , Ole Carstensen ¹ , Thomas Greve ⁶ , Karoline K?rgaard Hansen ² , Annett Dalb?ge ² , Esben Meulengracht Flachs ⁴ , Sanne Jespersen ⁷ , Mette Lausten Hansen ² , Susan Mikkelsen ⁸ , Marianne Kragh Thomsen ⁶ , Jacob Dvinge Redder ⁹ , Else Toft W?rtz ² , Lars ?stergaard ⁷ , Christian Erikstrup ⁸ , Henrik Albert Kolstad ¹⁰



Affiliations

• PMID: 34022336
• DOI: 10.1016/j.ijid.2021.05.032

Abstract

Objective: We aimed to compare symptoms day by day for non-hospitalised individuals tested positive and negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: We followed 210 test-positive and 630 test-negative health-care workers of the Central Denmark Region up to 90 days after the test, April-June 2020. They daily reported COVID-19 related symptoms that were compared graphically and by logistic regression.
Results: Thirty % of test-positive and close to zero of test-negative participants reported reduced sense of taste and smell during all 90 days (adjusted odds ratio [aOR] 86.07, 95% CI 22.86-323). Dyspnoea was reported by an initial 20% of test-positive declining to 5% after 30 days without ever reaching the level of the test-negative participants (aOR 6.88, 95% CI 2.41-19.63). Cough, headache, sore throat, muscle pain, and fever were temporarily more prevalent among the test positive participants; after 30 days, no increases were seen. Women and older participants were more susceptible to COVID-19 symptoms.
Conclusion: Prevalence of long-lasting reduced sense of taste and smell is highly increased in mild COVID-19 patients. This pattern is also seen for dyspnoea at a low level but not for cough, sore throat, headache, muscle pain, or fever.

Keywords: Ageusia; Anosmia; Dyspnoea; Long-haul COVID-19; Post-COVID-19; Post-acute COVID-19 syndrome.