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Circ J . Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan

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  • Circ J . Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan


    Circ J


    . 2021 May 20.
    doi: 10.1253/circj.CJ-21-0169. Online ahead of print.
    Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan


    Yugo Yamashita 1 , Yuuki Maruyama 2 , Hirono Satokawa 3 , Yuji Nishimoto 4 , Ichizo Tsujino 5 , Hideki Sakashita 6 , Hiroko Nakata 7 , Yoshinori Okuno 1 , Yoshito Ogihara 8 , Sen Yachi 9 , Naoki Toya 10 , Masami Shingaki 11 , Satoshi Ikeda 12 , Naoto Yamamoto 13 , Shizu Aikawa 14 , Nobutaka Ikeda 15 , Hiroya Hayashi 16 , Shingo Ishiguro 17 , Eriko Iwata 18 , Michihisa Umetsu 19 , Akane Kondo 20 , Takehisa Iwai 21 , Takao Kobayashi 13 , Makoto Mo 22 , Norikazu Yamada 23 , Taskforce of VTE and COVID-19 in Japan Study



    Affiliations

    Abstract

    Background: Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.Methods and Results:The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.6%) were evaluated with contrast-enhanced CT examination. VTE events occurred in 10 patients (22.2%), and the incidence of VTE in mild, moderate, and severe COVID-19 was 0%, 11.8%, and 40.0%, respectively. COVID-19 patients with VTE showed a higher body weight (81.6 vs. 64.0 kg, P=0.005) and body mass index (26.9 vs. 23.2 kg/m2, P=0.04), and a higher proportion had a severe status for COVID-19 compared with those without. There was no significant difference in the proportion of patients alive at discharge between patients with and without VTE (80.0% vs. 88.6%, P=0.48). Among 8 pulmonary embolism (PE) patients, all were low-risk PE.
    Conclusions: Among a relatively small number of patients undergoing contrast-enhanced CT examination in Japanese real-world clinical practice, there were no VTE patients among those with mild COVID-19, but the incidence of VTE seemed to be relatively high among severe COVID-19 patients, although all PE events were low-risk without significant effect on mortality risk.

    Keywords: Asians; Coronavirus disease 2019 (COVID-19); Japan; Pulmonary embolism; Venous thromboembolism.

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