Announcement

Collapse
No announcement yet.

Ann Clin Lab Sci . COVID-19 Cardiac Injury: An Important Cause of COVID-19 Related Morbidity and Mortality

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Ann Clin Lab Sci . COVID-19 Cardiac Injury: An Important Cause of COVID-19 Related Morbidity and Mortality


    Ann Clin Lab Sci


    . 2021 Mar;51(2):156-162.

    COVID-19 Cardiac Injury: An Important Cause of COVID-19 Related Morbidity and Mortality


    Elizabeth Ricks 1 , Amer Wahed 1 , Amitava Dasgupta 1 , L Maximilian Buja 2



    Affiliations
    • PMID: 33941554


    Abstract

    Objective: Although coronavirus disease 2019 (COVID-19) typically presents as a respiratory illness, co-existent cardiovascular symptomatology associated with an elevated serum troponin level has been identified as a risk factor for adverse outcomes. Our study addressed the need to correlate serum cardiovascular biomarkers with tissue pathology based on autopsy.
    Materials and methods: In 13 patients, we reviewed the clinical history and measurements of serum troponin and other biomarkers and correlated them with autopsy findings.
    Results: At autopsy, the 13 COVID-19 patients exhibited evidence of diffuse alveolar damage (DAD) and cardiomegaly (heart weights ranged from 380 to 1170 grams). Of the 13 patients, three had elevated troponin I and evidence of severe coronary artery disease (CAD) (cases 4, 5, and 11), while six had elevated troponin I without evidence of severe CAD (cases 1, 3, 6, 7, 8, and 9), and four had no clinical or pathological evidence of CAD. Of note, cases 7 and 9 had significantly elevated troponin I levels (8.84 ng/mL and 4.94 ng/mL, respectively). Several cases showed focal degenerative change or damage of cardiomyocytes. However, none of the cases had evidence of lymphocytic myocarditis.
    Conclusion: Although we observed elevated biomarkers of heart failure in some cases, it was not a consistent finding and did not correlate with evidence of myocarditis. The elevated biomarkers may reflect non-ischemic heart damage as a consequence of COVID-19 infection.

    Keywords: COVID-19; diffuse alveolar damage; myocardium; troponin.

Working...
X