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Cureus . Warm Autoimmune Hemolytic Anemia Associated With Asymptomatic SARS-CoV-2 Infection

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  • Cureus . Warm Autoimmune Hemolytic Anemia Associated With Asymptomatic SARS-CoV-2 Infection


    Cureus


    . 2021 Mar 25;13(3):e14101.
    doi: 10.7759/cureus.14101.
    Warm Autoimmune Hemolytic Anemia Associated With Asymptomatic SARS-CoV-2 Infection


    Joseph R Liput 1 , Kim Jordan 1 , Rini Patadia 1 , Elizabeth Kander 2



    Affiliations

    Abstract

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resultant coronavirus disease 2019 (COVID-19) are associated with several hematologic abnormalities, including immune thrombocytopenia, antiphospholipid syndrome, and autoimmune hemolytic anemia (AIHA). Initial case reports suggested immune dysregulation to be the underlying etiology of SARS-CoV-2-associated AIHA, as all reported cases involved patients with moderate to severe COVID-19, many of whom had underlying lymphoproliferative disorders. More recently, AIHA has been reported in patients with mildly symptomatic SARS-CoV-2 infection. Here, we detail a patient with asymptomatic SARS-CoV-2 infection who presented with severe, symptomatic anemia. Workup was consistent with warm autoimmune hemolytic anemia (WAIHA) secondary to SARS-CoV-2 infection.

    Keywords: anemia; coronavirus disease 2019 (covid-19); severe acute respiratory syndrome coronavirus 2 (sars-cov-2); warm autoimmune hemolytic anemia.

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