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J Neuroimmunol
. 2021 Feb 20;353:577523.
doi: 10.1016/j.jneuroim.2021.577523. Online ahead of print.
Acute transverse myelitis with Dysautonomia following SARS-CoV-2 infection: A case report and review of literature
MariaM Escobar 1 , Saurabh Kataria 2 , Erum Khan 3 , Roshan Subedi 4 , Medha Tandon 5 , Krithika Peshwe 1 , Joshua Kramer 1 , Faraze Niaze 1 , Shitiz Sriwastava 6
Affiliations
- PMID: 33640717
- DOI: 10.1016/j.jneuroim.2021.577523
Abstract
Objective: To report a unique case and literature review of post COVID-19 associated transverse myelitis and dysautonomia with abnormal MRI and CSF findings.
Background: Coronavirus disease have been reported to be associated with several neurological manifestations such as stroke, Guillain-Barr? syndrome, meningoencephalitis amongst others. There are only few reported cases of transverse myelitis with the novel coronavirus (n-CoV-2) and only one reported case identifying dysautonomia in COVID-19 patient. Here, we identify a COVID-19 patient diagnosed with acute transverse myelitis in addition to dysautonomia following with complete resolution of symptoms.
Method: A retrospective chart review of a patient diagnosed with post SARS-CoV-2 infection acute transverse myelitis and dysautonomia, and a review of literature of all the reported cases of transverse myelitis and COVID-19, from December 1st, 2019 till December 25th, 2020, was performed.
Conclusion: To our knowledge, this is the first reported case of transverse myelitis and dysautonomia in a patient with SARS-CoV-2 infection, who responded to intravenous methyl prednisone and bromocriptine. Follow-up imaging of the spine showed complete resolution of the lesion. Further studies would be recommended to identify the underlying correlation between COVID-19 and transverse myelitis.
Keywords: Autoimmune disorder; COVID-19; Coronavirus disease 2019; Dysautonomia; MRI spine; SARS-CoV-2; Transverse myelitis.