J Intern Med
. 2021 Feb 1.
doi: 10.1111/joim.13257. Online ahead of print.
Pathophysiological Mechanisms and Management of Patients with Long-time Anosmia related to COVID-19
Jerome R Lechien 1 2 3 4 , Carlos M Chiesa-Estomba 1 5 , St?phane Hans 1 3 , Sven Saussez 1 2 4
Affiliations
- PMID: 33527593
- DOI: 10.1111/joim.13257
Abstract
We carefully read the letter of Locatello et Oreste regarding our paper entitled "Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients."1 The authors2 highlighted an important unresolved issue: the pathophysiological mechanisms and the management of patients with long-term anosmia. As stated by authors, the development of anosmia is related to the infection of the sustentacular and basal cells, which highly express ACE-2.
Keywords: Anosmia; COVID-19; Coronavirus; Hyposmia; Olfactory; Recovery; SARS-CoV-2; Serology; Smell.