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IDCases
. 2021 Jan 12;e01047.
doi: 10.1016/j.idcr.2021.e01047. Online ahead of print.
Exuberant bullous vasculitis associated with SARS-CoV-2 infection
Pedro Alves da Cruz Gouveia 1 , Ingrid Cardoso Cipriano 1 , Marina Acevedo Zarzar de Melo 1 , Helena Texeira Araujo da Silva 1 , Matheus Augusto de Oliveira Amorim 1 , Clezio Cordeiro de S? Leit?o 1 , Maria Magalh?es Vasconcelos Guedes 1 , Daniela Mayumi Takano 2 , Norma Arteiro Filgueira 1 , Cl?udia Elise Ferraz 3
Affiliations
- PMID: 33457205
- PMCID: PMC7802587
- DOI: 10.1016/j.idcr.2021.e01047
Abstract
We described a case of exuberant cutaneous small-vessel vasculitis in a 27-year-old male with mild CoVID-19 in Brazil. The patient presented painful purpuric papules and vesicobullous lesions with hemorrhagic content located in the larger amount in the lower limbs and, to a lesser extent in the region of the back and upper limbs, saving palms and soles of the feet. Influenza-like syndrome with anosmia and ageusia was reported seven days before the skin lesions. A real-time reverse transcription polymerase chain reaction was positive on a nasopharyngeal swab for SARS-CoV-2. Histopathological study showed leukocytoclastic cutaneous vasculitis affecting small vessels and microthrombi occluding some vessels. The patient presented an improvement in skin lesions by the fifth day of prednisone therapy. This case highlights the importance of the SARS-CoV-2 test in investigating the etiology of cutaneous vasculitis during this pandemic.
Keywords: COVID-19; CSVV, cutaneous small-vessel vasculitis; CoVID-19, coronavirus disease; Coronavirus 2019; Coronavirus Infections; Cutaneous Leukocytoclastic Vasculitis; LCV, leukocytoclastic cutaneous vasculitis; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; rRT-PCR, real-time reverse transcription polymerase chain reaction.