Announcement

Collapse
No announcement yet.

Adv Clin Exp Med . Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An observational cohort study

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Adv Clin Exp Med . Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An observational cohort study


    Adv Clin Exp Med


    . 2020 Dec 31.
    doi: 10.17219/acem/130603. Online ahead of print.
    Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An observational cohort study


    Paweł Piwowarczyk 1 , Marta Szczukocka 1 , Paweł Kutnik 2 , Michał Borys 1 , Anna Mikłaszewska 3 , Sławomir Kiciak 3 , Mirosław Czuczwar 1



    Affiliations

    Abstract

    Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout Europe. However, there is a lack of data on the full clinical course of patients infected with SARS-CoV-2 in Europe, especially in the population that developed acute respiratory failure (ARF).
    Objectives: To identify risk factors associated with developing ARF during SARS-CoV-2 infection.
    Material and methods: This was an observational study of 60 adult patients with laboratory-confirmed SARS-CoV-2 infection. Data were collected from March 26, 2020 to May 26, 2020 in a tertiary academic hospital in Poland. All patients reached final outcome (discharge from the hospital or death). We divided patients into 2 groups based on whether they developed ARF, compared their clinical data, and performed multivariate logistic regression.
    Results: Twenty-two patients (36%) from the observed cohort developed ARF. Logistic regression identified that a high sequential organ failure assessment score at admission (odds ratio (OR) = 6.97 (1.57-30.90, p = 0.011)), and a long time from admission until pneumonia (OR = 1.41 (1.06-1.87, p = 0.016)), correlated with ARF development. D-dimer, lactate dehydrogenase, neutrophil to lymphocyte ratio, C-reactive protein (CRP), and interleukin 6 (IL-6) differed both statistically and clinically between ARF and non-ARF groups. The mortality rate in the observed cohort of patients was 13.3%, and it was 32% in the group that developed ARF.
    Conclusions: Routine vigilant examination of the above markers may identify patients at the highest risk of ARF early on during COVID-19 infection.

    Keywords: SARS; clinical characteristics; coronavirus; observational; respiratory failure.

Working...
X