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J Pediatr Hematol Oncol . Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis

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  • J Pediatr Hematol Oncol . Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis


    J Pediatr Hematol Oncol


    . 2020 Dec 23;Publish Ahead of Print.
    doi: 10.1097/MPH.0000000000002037. Online ahead of print.
    Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis


    Yogindra Persaud 1 , Mark Shamoun, Meera Chitlur, Kyle J Des Rosier, Jeffrey W Taub



    Affiliations

    Abstract

    The Coronavirus Disease 2019 (COVID-19) pandemic has become the worst pandemic in modern history. The lack of prior immunity to the virus has resulted in a high mortality rate, though children have fared better than adults, overall. We present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection. It is possible that this viral infection provided the "second hit" posited to occur in pediatric leukemogenesis as proposed by Dr Greaves, with his initial viral exposure occurring several weeks earlier.


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