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J Mol Cell Biol
. 2020 Nov 23;mjaa064.
doi: 10.1093/jmcb/mjaa064. Online ahead of print.
COVID-19 and cardiovascular diseases
Fan Liu 1 , Feng Liu 2 3 4 , Lu Wang 1
Affiliations
- PMID: 33226078
- DOI: 10.1093/jmcb/mjaa064
Abstract
The coronavirus disease 2019 (COVID-19) remains a global public health emergency. Despite being caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), besides the lung, this infectious disease also has severe implications in cardiovascular system. In this review, we summarize diverse clinical complications of heart and vascular system, as well as the relevant high mortality, in COVID-19 patients. Systemic inflammation and angiotensin-converting enzyme 2-involved signaling networking in SARS-CoV-2 infection and cardiovascular system may contribute to the manifestations of cardiovascular diseases. Therefore, integration of clinical observations and experimental findings can promote our understanding of the underlying mechanisms, which would aid in identifying and treating the cardiovascular injury in patients with COVID-19 appropriately.
Keywords: ACE2; COVID-19; SARS-CoV-2; cardiovascular diseases; systemic inflammation.