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J Infect Chemother . Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19)

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  • J Infect Chemother . Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19)


    J Infect Chemother


    . 2020 Sep 30;S1341-321X(20)30350-0.
    doi: 10.1016/j.jiac.2020.09.030. Online ahead of print.
    Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19)


    Yuki Kasuga 1 , Koji Nishimura 1 , Hidetoshi Go 1 , Kimitaka Nakazaki 1 , Shoichi Shimizu 1 , Koji Kanezawa 1 , Makoto Tanaka 2 , Takeshi Oshima 2 , Ichiro Morioka 3



    AffiliationsFree PMC article

    Abstract

    Coronavirus disease (COVID-19) is often characterized by abnormal olfactory and gustatory symptoms in adults; however, detailed studies on pediatric patients with COVID-19 are extremely limited. A 13-year-old Japanese girl presented with fever and cough, and after 2 days, her olfactory and taste sensations suddenly disappeared. A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed using a nasopharyngeal swab. Because a positive result was seen, she was admitted on the 7th day of illness. On admission, the visual analogue scale (VAS) score for smell and taste was 0 of 100%. An intravenous olfaction test using prosultiamine (Alinamin test) was performed on the 15th day of illness to evaluate olfaction, and an increase in latency (33 seconds) and a decrease in duration (55 seconds) were observed. In the odor identification test using 12 different odor cards, only 7 odors were correctly identified. On the 18th day of illness, SARS-CoV-2 tested negative in the RT-PCR test; simultaneously, the VAS score for smell and taste fully improved to 100 of 100%. On the 77th day of illness, full recovery was confirmed in the Alinamin test (latency, 7 seconds; duration, 82 seconds). In this present case, an improvement in olfactory and gustatory dysfunctions was observed with negative results in RT-PCR test for SARS-CoV-2.

    Keywords: Angiotensin-converting enzyme 2 receptor; Intravenous olfaction test; Real-time reverse transcriptase-polymerase chain reaction; Visual analogue scale.

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