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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue . Correlation between hyponatremia and the severity of coronavirus disease 2019

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  • Zhonghua Wei Zhong Bing Ji Jiu Yi Xue . Correlation between hyponatremia and the severity of coronavirus disease 2019


    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue


    . 2020 Jul;32(7):774-778.
    doi: 10.3760/cma.j.cn121430-20200331-00417.
    [Correlation between hyponatremia and the severity of coronavirus disease 2019]


    [Article in Chinese]

    Weidai Zhang 1 , Senrong Lu 2 , Mianfeng Zhang 3 , Hongbin Zheng 4 , Yuhan Huang 5 , Suzhi Chen 3 , Huizhong Kang 6 , Suwu Wu 3



    Affiliations

    Abstract

    Objective: To investigate the correlation between hyponatremia and the severity of coronavirus disease 2019 (COVID-19).
    Methods: Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Na+ level in the patients with COVID-19.
    Results: Among the 12 patients with COVID-19, there were 8 males and 4 females with the mean age of (38.0?16.3) years old, most of them were admitted to the hospital with cough and/or fever. All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. All patients were of ordinary type when they were admitted to the hospital. Among them, 1 patient turned into a severe case during the course of the disease, and 1 patient showed a tendency to become severe case. It was found that 10 patients without severe conversion had an average blood Na+ of (138.3?1.3) mmol/L at admission, and the lowest blood Na+ during the course of disease was (135.9?3.1) mmol/L. However, 2 patients who became severe and had a tendency to become severe disease (Na+ levels at admission were 140.0 mmol/L and 138.0 mmol/L, respectively) experienced hyponatremia during the course of the disease (the lowest blood Na+ levels were 129.0 mmol/L and 122.0 mmol/L). Further analysis showed that the lower serum Na+ level, the higher level of white blood cell count (WBC) and C-reactive protein (CRP), but serum Na+ level was consistent with the change trend of lymphocytes, suggesting that hyponatremia was closely correlated with severe inflammation reaction.
    Conclusions: Serum Na+ showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. It was necessary to pay great attention to the change trend of blood Na+ level. However, further research was needed to obtain more reliable conclusions and explorer the pathophysiological mechanisms.


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