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J Med Virol
. 2020 Jul 10.
doi: 10.1002/jmv.26294. Online ahead of print.
Extra-pulmonary Complications of COVID-19: A Multi-System Disease?
Kenneth I Zheng 1 , Gong Feng 2 , Wen-Yue Liu 3 , Giovanni Targher 4 , Christopher D Byrne 5 , Ming-Hua Zheng 1
Affiliations
- PMID: 32648973
- DOI: 10.1002/jmv.26294
Abstract
The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently declared a pandemic by the World Health Organization. In addition to its acute respiratory manifestations, SARS-CoV-2 may also adversely affect other organ systems. To date, however, there is very limited understanding of the extent and management of COVID-19-related conditions outside of the pulmonary system. This narrative review provides an overview of the current literature about the extra-pulmonary manifestations of COVID-19 that may affect the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. This review also describes current understanding of the extra-pulmonary complications caused by COVID-19 in order to improve the management and prognosis of patients with COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; extra-pulmonary manifestations; management.