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J Pediatric Infect Dis Soc . SARS-CoV-2 Infection in Febrile Neonates

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  • J Pediatric Infect Dis Soc . SARS-CoV-2 Infection in Febrile Neonates


    J Pediatric Infect Dis Soc


    . 2020 Jul 9;piaa084.
    doi: 10.1093/jpids/piaa084. Online ahead of print.
    SARS-CoV-2 Infection in Febrile Neonates


    Hanna Wardell 1 2 , Jeffrey I Campbell 1 2 , Christina VanderPluym 3 2 , Avika Dixit 1 2



    Affiliations

    Abstract

    Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of four full term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Two neonates required admission to the intensive care unit for respiratory insufficiency and end organ involvement. Half of the patients were found to have a co-infection. One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. All neonates had favorable outcomes.

    Keywords: COVID-19; SARS-CoV-2; infant; neonatal sepsis; remdesivir.

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