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Thromb Res . Mechanisms Involved in the Development of Thrombocytopenia in Patients With COVID-19

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  • Thromb Res . Mechanisms Involved in the Development of Thrombocytopenia in Patients With COVID-19


    Thromb Res


    . 2020 Jun 5;193:110-115.
    doi: 10.1016/j.thromres.2020.06.008. Online ahead of print.
    Mechanisms Involved in the Development of Thrombocytopenia in Patients With COVID-19


    Yujiao Zhang 1 , Xiaoyuan Zeng 1 , Yingying Jiao 1 , Zongpeng Li 1 , Qifa Liu 1 , Mo Yang 2 , Jieyu Ye 3



    AffiliationsFree PMC article

    Abstract

    Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia. Thrombocytopenia was detected in 5-41.7% of the patients with COVID-19. Analyzing the dynamic decrease in platelet counts may be useful in the prognosis of patients with COVID-19. However, the mechanisms underlying the development of thrombocytopenia remain to be elucidated. This review summarizes the hematological changes in patients infected with SARS-CoV-2 and possible underlying mechanisms of thrombocytopenia development.

    Keywords: COVID-19; SARS-CoV-2; Thrombocytopenia.

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