Neurology Neurologic Manifestations in Hospitalized Patients With COVID-19: The ALBACOVID Registry

[tetano]

Neurology


. 2020 Jun 1;10.1212/WNL.0000000000009937.
doi: 10.1212/WNL.0000000000009937. Online ahead of print.
Neurologic Manifestations in Hospitalized Patients With COVID-19: The ALBACOVID Registry


Carlos Manuel Romero-S?nchez ¹ , Inmaculada D?az-Maroto ¹ , Eva Fern?ndez-D?az ¹ , ?lvaro S?nchez-Larsen ¹ , Almudena Layos-Romero ¹ , Jorge Garc?a-Garc?a ¹ , Esther Gonz?lez ¹ , Inmaculada Redondo-Pe?as ¹ , Ana Bel?n Perona-Moratalla ¹ , Jos? Antonio Del Valle-P?rez ¹ , Julia Gracia-Gil ¹ , Laura Rojas-Bartolom? ¹ , Inmaculada Feria-Vilar ¹ , Mar?a Monteagudo ¹ , Mar?a Palao ¹ , Elena Palaz?n-Garc?a ¹ , Cristian Alcahut-Rodr?guez ¹ , David Sopelana-Garay ¹ , Y?scar Moreno ¹ , Javaad Ahmad ¹ , Tom?s Segura



Affiliations

• PMID: 32482845
• DOI: 10.1212/WNL.0000000000009937

Abstract

Objective: The coronavirus disease 2019 (COVID-19) has spread worldwide since December 2019. Neurological symptoms have been reported as part of the clinical spectrum of the disease. We aim to determine whether neurological manifestations are common in hospitalized COVID-19 patients and to describe their main characteristics.
Methods: We systematically review all patients diagnosed with COVID-19 admitted to hospital in a Spanish population during March 2020. Demographic characteristics, systemic and neurological clinical manifestations, and complementary tests were analyzed.
Results: Of 841 patients hospitalized with COVID-19 (mean age 66.4 years, 56.2% men) 57.4% developed some form of neurological symptom. Nonspecific symptoms such as myalgias (17.2%), headache (14.1%), and dizziness (6.1%) were present mostly in the early stages of infection. Anosmia (4.9%) and dysgeusia (6.2%) tended to occur early (60% as the first clinical manifestation) and were more frequent in less severe cases. Disorders of consciousness occurred commonly (19.6%), mostly in older patients and in severe and advanced COVID-19 stages. Myopathy (3.1%), dysautonomia (2.5%), cerebrovascular diseases (1.7%), seizures (0.7%), movement disorders (0.7%), encephalitis (n=1), Guillain-Barr? syndrome (n=1), and optic neuritis (n=1) were also reported, but less frequent. Neurological complications were the main cause of death in 4.1% of all deceased study subjects.
Conclusions: Neurological manifestations are common in hospitalized COVID-19 patients. In our series, more than half of patients presented some form of neurological symptom. Clinicians need to maintain close neurological surveillance for prompt recognition of these complications. The investigation of the mechanisms and emerging consequences of SARS-CoV-2 neurological involvement require further studies.




? 2020 American Academy of Neurology.