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Clin Exp Dermatol. 2020 May 8. doi: 10.1111/ced.14277. [Epub ahead of print]
Clinical and histological characterization of vesicular COVID-19 rashes: A prospective study in a tertiary care hospital.
Fernandez-Nieto D1, Ortega-Quijano D1, Jimenez-Cauhe J1, Burgos-Blasco P1, de Perosanz-Lobo D1, Suarez-Valle A1, Cortes-Cuevas JL2, Carretero I3, Garcia Del Real CM3, Fernandez-Guarino M1.
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Abstract
Vesicular skin rashes have been associated to the Coronavirus Disease 2019 (COVID-19), but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID-19 and vesicular lesions. Clinical characterization of skin findings was conducted by dermatologists. When possible, histological analysis and detection of severe acute respiratory coronavirus 2 (SARS-CoV-2) in the content of the vesicles was performed. A total of 24 patients were included. A disseminated pattern was found in 18 patients (75%), and a localized pattern was found in 6 patients (25%). The median duration of the skin rash was of 10 days. Out of all, 19 patients (79.2%) presented the skin rash after the onset of COVID-19 symptoms. Histologic examination in two patients was consistent with viral infection, SARS-CoV-2 was not detected in four patients. This monocentric study shows the clinical characteristics of vesicular skin rashes in COVID-19 patients.
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PMID:32384180DOI:10.1111/ced.14277