Announcement

Collapse
No announcement yet.

Rev Esp Enferm Dig. Covid-19, Coronavirus, SARS-CoV-2 and the small bowel

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Rev Esp Enferm Dig. Covid-19, Coronavirus, SARS-CoV-2 and the small bowel


    Rev Esp Enferm Dig. 2020 Apr 28. doi: 10.17235/reed.2020.7137/2020. [Epub ahead of print]
    Covid-19, Coronavirus, SARS-CoV-2 and the small bowel.


    M?nkem?ller K1, Fry L2, Rickes S3.

    Author information




    Abstract

    Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site, as the enterocytes are rich in angiotensin converting enzyme (ACE)-2 receptors. The initial gastrointestinal symptoms that appear early during the course of Covid-19 support this hypothesis. Furthermore, SARS-CoV virions are preferentially released apically and not at the basement of the airway cells. Thus, in the setting of a productive infection of conducting airway epithelia, the apically released SARS-CoV may be removed by mucociliary clearance and gain access to the GI tract via a luminal exposure. In addition, post-mortem studies of mice infected by SARS-CoV have demonstrated diffuse damage to the GI tract, with the small bowel showing signs of enterocyte desquamation, edema, small vessel dilation and lymphocyte infiltration, as well as mesenteric nodes with severe hemorrhage and necrosis. Finally, the small bowel is rich in furin, a serine protease which can separate the S-spike of the coronavirus into two "pinchers" (S1 and 2). The separation of the S-spike into S1 and S2 is essential for the attachment of the virion to both the ACE receptor and the cell membrane. In this special review, we describe the interaction of SARS-CoV-2 with the cell and enterocyte and its potential clinical implications.



    PMID:32343593DOI:10.17235/reed.2020.7137/2020
    Free full text

Working...
X