J Med Virol. 2020 Apr 21. doi: 10.1002/jmv.25915. [Epub ahead of print]
Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2).
Paniz-Mondolfi A1, Bryce C1, Grimes Z1, Gordon RE1, Reidy J1, Lednicky J2, Sordillo EM1, Fowkes M1.
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Abstract
Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with Severe Acute Respiratory Syndrome Coronavirus-2. Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying CNS involvement. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
CNS infection; SARS-CoV-2; endothelium; neuroinvasion; neurotropism
PMID:32314810DOI:10.1002/jmv.25915