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Int J Stroke. Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature

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  • Int J Stroke. Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature


    Int J Stroke. 2020 Apr 20:1747493020921664. doi: 10.1177/1747493020921664. [Epub ahead of print]
    Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature.


    Aggarwal G1, Lippi G2, Michael Henry B3.

    Author information




    Abstract

    INTRODUCTION:

    There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.
    METHOD:

    We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19.
    RESULTS:

    A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection.
    DISCUSSION:

    Our findings are limited by a small number of studies and sample size.
    CONCLUSION:

    There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.



    KEYWORDS:

    COVID-19; Cerebrovascular disease; Coronavirus


    PMID:32310015DOI:10.1177/1747493020921664

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