Crit Care Resusc. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis

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Crit Care Resusc. 2020 Apr 15. [Epub ahead of print]
Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis.


Ciceri F¹, Beretta L², Scandroglio AM², Colombo S², Landoni G³, Ruggeri A¹, Peccatori J¹, D'Angelo A⁴, De Cobelli F², Rovere-Querini P², Tresoldi M⁵, Dagna L², Zangrillo A².

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Abstract

We suggest the use of MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome) as a new name for severe pulmonary coronavirus disease 2019 (COVID-19). We hypothesise that, in predisposed individuals, alveolar viral damage is followed by an inflammatory reaction and by microvascular pulmonary thrombosis. This progressive endothelial thromboinflammatory syndrome may also involve the microvascular bed of the brain and other vital organs, leading to multiple organ failure and death. Future steps in the understanding of the disease and in the identification of treatments may benefit from this definition and hypothesised sequence of events.



KEYWORDS:

COVID-19


PMID:32294809