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Eur J Heart Fail. Myocardial localization of coronavirus in COVID-19 cardiogenic shock

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  • Eur J Heart Fail. Myocardial localization of coronavirus in COVID-19 cardiogenic shock


    Eur J Heart Fail. 2020 Apr 10. doi: 10.1002/ejhf.1828. [Epub ahead of print]
    Myocardial localization of coronavirus in COVID-19 cardiogenic shock.


    Tavazzi G1,2, Pellegrini C1,3, Maurelli M4, Belliato M2, Sciutti F2, Bottazzi A2, Sepe PA5, Resasco T5, Camporotondo R6, Bruno R1,7, Baldanti F1,8, Paolucci S8, Pelenghi S3, Iotti GA1,2, Mojoli F1,2, Arbustini E9.

    Author information




    Abstract

    We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.
    © 2020 European Society of Cardiology.



    KEYWORDS:

    Cardiac injury; Cardiogenic shock; Coronavirus; Extracorporeal membrane oxygenation; Myocardial inflammation; SARS-CoV-2


    PMID:32275347DOI:10.1002/ejhf.1828

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