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Clin Infect Dis. Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery

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  • Clin Infect Dis. Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery


    Clin Infect Dis. 2020 Mar 30. pii: ciaa271. doi: 10.1093/cid/ciaa271. [Epub ahead of print]
    Novel Coronavirus Pneumonia (COVID-19) Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery.


    Han X1,2, Cao Y1,2, Jiang N1,2, Chen Y1,2, Alwalid O1,2, Zhang X, Gu J1,2, Dai M1,2, Liu J1,2, Zhu W3, Zheng C1,2, Shi H1,2.

    Author information




    Abstract

    BACKGROUND:

    To retrospectively analyze the evolution of clinical features and thin-section CT imaging of novel coronavirus pneumonia (COVID-19) in 17 discharged patients.
    METHODS:

    Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and CT pattern were documented in all patients during 4 weeks since admission. CT score was used to evaluate the extent of the disease.
    RESULTS:

    There was a marked improvement of fever, lymphocytes count, C-reactive protein and erythrocyte sedimentation rate within the first two weeks since admission. However, the mean CT score rapidly increased from the 1st to 3rd week, with a top score of 8.2 obtained in the 2nd week. During the 1st week, the main CT pattern was ground-glass opacities (GGO,76.5%). The frequency of GGO (52.9%) decreased in the 2nd week. Consolidation and mixed patterns (47.0%) were noted in the 2nd week. Thereafter, consolidations generally dissipated into GGO and the frequency of GGO increased in the 3rd week (76.5%) and 4th week (71.4%). Opacities were mainly located in the peripheral (76.5%), subpleural (47.1%) zones of the lungs, and presented as focal (35.3%) or multifocal (29.4%) in the 1st week and became more diffuse in the 2nd (47.1%) and 3rd week (58.8%), then showed reduced extent in 4th week (50%).
    CONCLUSIONS:

    The progression course of CT pattern was later than the clinical parameters within the first two weeks since admission; however, there was a synchronized improvement in both clinical and radiologic features in the 4th week.
    ? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.



    KEYWORDS:

    COVID-19; computed tomography; novel coronavirus pneumonia; viral pneumonia


    PMID:32227091DOI:10.1093/cid/ciaa271

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