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Liver Transpl. 2020 Mar 20. doi: 10.1002/lt.25756. [Epub ahead of print]
Coronaviruses and immunosuppressed patients. The facts during the third epidemic.
D'Antiga L1.
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Abstract
Following the outbreak in China, the Lombardy region of Italy has become one of the areas of highest incidence of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). As the outbreak grew to a pandemic, many centres worldwide raised the concern that immunocompromised patients may be at high risk of developing a severe respiratory disease called COVID-19. Unlike common viral agents (such as Adenovirus, Rhinovirus, Norovirus, Influenza, Respiratory Syncytial Virus), Coronaviruses have not shown to cause a more severe disease in immunosuppressed patients. For this family of viruses the host innate immune response appears the main driver of lung tissue damage during infection.
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KEYWORDS:
Coronavirus; SARS; SARS-CoV-2,COVID-19; children; immunosuppression; liver; transplantation; viral infection
PMID:32196933DOI:10.1002/lt.25756