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Arch Virol. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

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  • Arch Virol. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

    Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. (Arch Virol., abstract, edited)

    3. Arch Virol. 2010;155(1):83-7. Epub 2009 Nov 20.

    Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

    Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. - Department of Medicine, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD 21201, USA.

    Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.

    PMID: 19936613 [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms, Secondary Source ID, Grant Support
    Publication Types:

    * Research Support, N.I.H., Extramural

    MeSH Terms:

    * Evolution, Molecular*
    * Genome, Viral*
    * Humans
    * Molecular Sequence Data
    * Phylogeny
    * Picornaviridae Infections/virology*
    * Respiratory Tract Infections/virology*
    * Rhinovirus/classification*
    * Rhinovirus/genetics*
    * Rhinovirus/isolation & purification

    Secondary Source ID:

    * GENBANK/GQ415051
    * GENBANK/GQ415052

    Grant Support:

    * HL071609/HL/NHLBI NIH HHS/United States

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