Front Bioeng Biotechnol. 2018 Feb 8;6:11. doi: 10.3389/fbioe.2018.00011. eCollection 2018.
Ethical and Philosophical Considerations for Gain-of-Function Policy: The Importance of Alternate Experiments.

Evans NG1.
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The Department of Health and Human Services Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens (PPPs) contains a series of principles for governing the funding and conduct of gain-of-function (GOF) research resulting in the creation of PPPs. In this article, I address one of these principles, governing the replacement of GOF research with alternate experiments. I argue that the principle fails to address the way that different experiments can promote the same values as those promoted by GOF research resulting in PPPs. I then address some objections to this claim, and provide policy recommendations moving forward.


bioethics; biosafety; biosecurity; coronavirus; dual-use research; gain-of-function; highly pathogenic avian influenza virus

PMID: 29473036 PMCID: PMC5809449 DOI: 10.3389/fbioe.2018.00011