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Sleep Med Clin. 2017 Sep;12(3):279-287. doi: 10.1016/j.jsmc.2017.03.004. Epub 2017 May 26.
The Immune Basis of Narcolepsy: What Is the Evidence?
Taheri S1.
Author information
Abstract
Narcolepsy is a chronic neurologic sleep disorder. Type 1 narcolepsy (narcolepsy-cataplexy) is associated with the destruction of lateral hypothalamic hypocretin neurons. It is thought that the loss of hypocretin neurons is autoimmune mediated. This is because of the close relationship between type 1 narcolepsy and HLA DQB1∗0602 and the onset of narcolepsy at a young age. Evidence suggests that streptococcal and H1N1 influenza infections (and H1N1 vaccination) may be involved in the pathogenesis of narcolepsy. There are suggestions from genetic and immune studies that the immune system plays a key role in narcolepsy.
Copyright ? 2017 Elsevier Inc. All rights reserved.
KEYWORDS:
Autoimmune; Human leukocyte antigen; Influenza; Narcolepsy
PMID: 28778227 DOI: 10.1016/j.jsmc.2017.03.004
The Immune Basis of Narcolepsy: What Is the Evidence?
Taheri S1.
Author information
Abstract
Narcolepsy is a chronic neurologic sleep disorder. Type 1 narcolepsy (narcolepsy-cataplexy) is associated with the destruction of lateral hypothalamic hypocretin neurons. It is thought that the loss of hypocretin neurons is autoimmune mediated. This is because of the close relationship between type 1 narcolepsy and HLA DQB1∗0602 and the onset of narcolepsy at a young age. Evidence suggests that streptococcal and H1N1 influenza infections (and H1N1 vaccination) may be involved in the pathogenesis of narcolepsy. There are suggestions from genetic and immune studies that the immune system plays a key role in narcolepsy.
Copyright ? 2017 Elsevier Inc. All rights reserved.
KEYWORDS:
Autoimmune; Human leukocyte antigen; Influenza; Narcolepsy
PMID: 28778227 DOI: 10.1016/j.jsmc.2017.03.004