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_|selected Research Articles Abstracts, July 27, 2008|_

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  • _|selected Research Articles Abstracts, July 27, 2008|_

    [In this post: (1) Research Articles Abstracts.

    (1.1) Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in the cynomolgus macaques.

    (1.2) Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia.

    (1.3) What about viral community acquired pneumonias?

    (1.4) Simultaneously subtyping of all influenza A viruses using DNA microarrays.

    (1.5) Evaluation of chicken-origin (DF-1) and quail-origin (QT-6) fibroblast cell lines for replication of avian influenza viruses.

    (1.6) Preparedness for pandemic influenza in nursing homes: a 2-state survey.

    (1.7) Protecting residential care facilities from pandemic influenza.

    (1.8) Estimating the impact of childhood influenza vaccination programmes in England and Wales.

    (1.9) Influenza vaccine in Hajj pilgrims: Policy issues from field studies.

    (1.10) Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.

    (1.11) Safety and reactogenicity profile of an adjuvanted H5N1 pandemic candidate vaccine in adults within a phase III safety trial.

    See original abstracts at the source site. EDITED.]
    (1.1): Antiviral Res. 2008 Jul 19. [Epub ahead of print]

    Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in the cynomolgus macaques.

    Stittelaar KJ, Tisdale M, van Amerongen G, van Lavieren RF, Pistoor F, Simon J, Osterhaus AD. - ViroClinics BV, Rotterdam, The Netherlands.

    We investigated the prophylactic and therapeutic efficacy of an intravenous (IV) formulation of zanamivir in a macaque infection model for highly pathogenic influenza A (H5N1) virus.
    Antiviral efficacy was dose-dependent, with no reduction in viral load observed at 2mg/kg, but a significant reduction observed at 10mg/kg (p=0.039) and at 20mg/kg in the combined prophylactic and therapeutic groups (p=0.049) with both prophylaxis (commencing 12h before infection) and therapy (commencing 4h after infection) showing similar reductions in viral load.
    Combined gross pathology and microscopic pneumonia scores in the treated animals relative to untreated controls were significantly reduced at 10mg/kg (p=0.02) and at 20mg/kg in the prophylaxis group (p=0.02), but were not significant in the treatment group (p=0.145).
    In this new animal model for evaluation of influenza antivirals, despite variability observed between individual animals, IV zanamivir showed evidence of efficacy against highly pathogenic H5N1 virus.

    PMID: 18647621 [PubMed - as supplied by publisher]
    (1.2): Arch Virol. 2008 Jul 25. [Epub ahead of print]

    Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia.

    Isoda N, Sakoda Y, Kishida N, Soda K, Sakabe S, Sakamoto R, Imamura T, Sakaguchi M, Sasaki T, Kokumai N, Ohgitani T, Saijo K, Sawata A, Hagiwara J, Lin Z, Kida H. - Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18-jyo Nishi-9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.

    A reassortant influenza virus, A/duck/Hokkaido/Vac-1/2004 (H5N1) (Dk/Vac-1/04), was generated between non-pathogenic avian influenza viruses isolated from migratory ducks in Asia.
    Dk/Vac-1/04 (H5N1) virus particles propagated in embryonated chicken eggs were inactivated with formalin and adjuvanted with mineral oil to form a water-in-oil emulsion.
    The resulting vaccine was injected intramuscularly into chickens.
    The chickens were challenged with either of the highly pathogenic avian influenza virus strains A/chicken/Yamaguchi/7/2004 (H5N1) or A/swan/Mongolia/3/2005 (H5N1) at 21 days post-vaccination (p. v.), when the geometric mean serum HI titers of the birds was 64 with the challenge virus strains.
    The vaccinated chickens were protected from manifestation of disease signs upon challenge with either of the highly pathogenic avian influenza viruses.
    However, challenge virus was recovered at low titers from the birds at 2 and 4 days post-challenge (p.c.).
    All 3 chickens challenged at 6 days p.v. died, whereas 3 chickens challenged at 8 days p.v. survived.
    These results indicate that the present vaccine confers clinical protection and reduction of virus shedding against highly pathogenic avian influenza virus challenge and should be useful as an optional tool in emergency cases.

    PMID: 18651092 [PubMed - as supplied by publisher]
    (1.3): BMJ. 2008 Jul 1;337:a598. doi: 10.1136/bmj.a598.
    Comment on: BMJ. 2008 Jun 21;336(7658):1429-33.

    What about viral community acquired pneumonias?
    Shin GY.
    PMID: 18595907 [PubMed - indexed for MEDLINE] - PMCID: PMC2443564
    (1.4): J Virol Methods. 2008 Jul 17. [Epub ahead of print]

    Simultaneously subtyping of all influenza A viruses using DNA microarrays.

    Han X, Lin X, Liu B, Hou Y, Huang J, Wu S, Liu J, Mei L, Jia G, Zhu Q. - Chinese Academy of Inspection and Quarantine, Beijing 100029, China.

    Rapid diagnosis of novel emerging subtypes of influenza viruses is vital for effective global influenza surveillance.
    To this end, a novel microarray based surveillance was developed for subtyping all influenza A viruses on one chip.
    Using reference strains of different influenza subtypes and samples from different areas, the results show that all the subtypes of the influenza A virus could be identified simultaneously on this microchip with high sensitivity.
    There was no cross-hybridization reaction with other viruses, indicating that the microarray is specific for influenza A viruses.
    Such a diagnostic microarray will undoubtedly be useful for identifying novel influenza A virus subtypes.
    PMID: 18639939 [PubMed - as supplied by publisher]
    (1.5): J Virol Methods. 2008 Jul 15. [Epub ahead of print]

    Evaluation of chicken-origin (DF-1) and quail-origin (QT-6) fibroblast cell lines for replication of avian influenza viruses.

    Lee CW, Jung K, Jadhao SJ, Suarez DL. - Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, United States; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, United States.

    Avian influenza viruses (AIVs) are isolated routinely and propagated in specific pathogen free embryonated chicken eggs (ECE) and mammalian origin Madin-Darby Canine Kidney (MDCK) cell line.
    Continuous avian cell lines offer advantages for propagation of AIVs over MDCK cells because they maintain species specificity, and lower recurring costs compared to ECE.
    In this study, the characteristics of two avian fibroblast cell lines were evaluated, DF-1 (chicken-origin) and QT-6 (quail-origin), and their ability to support the growth of AIVs (n=19) belonging to nine different hemagglutinin subtypes from a variety of avian species.
    The replication efficiency of the AIVs in QT-6 and DF-1 cells was comparable to those in primary chicken embryo fibroblast (CEF) and MDCK cells.
    Receptor distribution analysis demonstrated high prevalence of SA alpha2,3-gal linked receptors in QT-6 and DF-1 cells which support a high growth of AIVs in these cell lines.
    Furthermore, the QT-6 and DF-1 cells supported high plaque-forming ability of representative highly pathogenic Eurasian H5N1 and H7N1 subtype AIVs.
    These two avian cell lines, especially QT-6 cells, also showed high transfection efficiency and could be useful for reverse genetics based rescue of AIVs.
    This study indicates that the DF-1 and QT-6 cell lines may be useful as a substitute for primary CEF and MDCK cells for AIV research in the areas of in vitro host range, molecular pathobiology and molecular genetics.

    PMID: 18638503 [PubMed - as supplied by publisher]
    (1.6): JAMA. 2008 Jul 23;300(4):392-4.

    Preparedness for pandemic influenza in nursing homes: a 2-state survey.
    Smith PW, Shostrom V, Smith A, Kaufmann M, Mody L.
    PMID: 18647981 [PubMed - in process]
    (1.7): Proc Natl Acad Sci U S A. 2008 Jul 22. [Epub ahead of print]

    Protecting residential care facilities from pandemic influenza.

    Nu?o M, Reichert TA, Chowell G, Gumel AB. - Department of Biostatistics, School of Public Health, University of California, Los Angeles, CA 90095-1772;

    It is widely believed that protecting health care facilities against outbreaks of pandemic influenza requires pharmaceutical resources such as antivirals and vaccines.
    However, early in a pandemic, vaccines will not likely be available and antivirals will probably be of limited supply.
    The containment of pandemic influenza within acute-care hospitals anywhere is problematic because of open connections with communities.
    However, other health care institutions, especially those providing care for the disabled, can potentially control community access.
    We modeled a residential care facility by using a stochastic compartmental model to address the question of whether conditions exist under which nonpharmaceutical interventions (NPIs) alone might prevent the introduction of a pandemic virus.
    The model projected that with currently recommended staff-visitor interactions and social distancing practices, virus introductions are inevitable in all pandemics, accompanied by rapid internal propagation.
    The model identified staff reentry as the critical pathway of contagion, and provided estimates of the reduction in risk required to minimize the probability of a virus introduction.
    By using information on latency for historical and candidate pandemic viruses, we developed NPIs that simulated notions of protective isolation for staff away from the facility that reduced the probability of bringing the pandemic infection back to the facility to levels providing protection over a large range of projected pandemic severities.
    The proposed form of protective isolation was evaluated for social plausibility by collaborators who operate residential facilities.
    It appears unavoidable that NPI combinations effective against pandemics more severe than mild imply social disruption that increases with severity.
    PMID: 18647829 [PubMed - as supplied by publisher]
    (1.8): Vaccine. 2008 Jul 19. [Epub ahead of print]

    Estimating the impact of childhood influenza vaccination programmes in England and Wales.

    Vynnycky E, Pitman R, Siddiqui R, Gay N, Edmunds WJ. - Modelling and Economics Unit, Health Protection Agency Centre for Infections, 61 Colindale Avenue, Colindale, London NW9 5HT, UK.

    There is increasing interest in routine vaccination of children against influenza.
    We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively.
    The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively.
    These results are sensitive to assumptions about contact patterns and several parameters require further study.
    Consistently, high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.

    PMID: 18647634 [PubMed - as supplied by publisher]
    (1.9): Vaccine. 2008 Jul 17. [Epub ahead of print]

    Influenza vaccine in Hajj pilgrims: Policy issues from field studies.

    Rashid H, Shafi S, Haworth E, Memish ZA, El Bashir H, Ali KA, Booy R. - Academic Unit of Child Health, Barts and The London Queen Mary's School of Medicine and Dentistry, UK.

    In pilgrims returning to the UK from the Hajj in 2005 and 2006, protection from PCR-confirmed influenza by influenza vaccine was estimated using verified vaccination histories from those with symptoms consistent with influenza.
    Of 538 patients whose nasal swabs were analysed and immunisation histories confirmed 115 (21%) were in a high-risk group for influenza; half of these (58/115) were immunised against influenza, compared with a fifth (90/423) of those not at high risk.
    Five percent of vaccinated 'at risk' pilgrims compared with 14% of unvaccinated (RR 0.37, 95% CI 0.1-1.4) had confirmed influenza.
    Rates of influenza in vaccinated and unvaccinated 'not at risk' pilgrims were similar (10% vs. 11%).
    Seasonal influenza vaccine was insignificantly protective against influenza in Hajj pilgrims.

    PMID: 18640171 [PubMed - as supplied by publisher]
    (1.10): Vaccine. 2008 Jul 16. [Epub ahead of print]

    Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.

    Esposito S, Gasparini C, Martelli A, Zenga A, Tremolati E, Varin E, Marseglia GL, Fiocchi A, Principi N. - Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, 20122 Milan, Italy.

    In order to evaluate whether the virosomal adjuvanted influenza vaccine that has been shown to have the lowest egg protein content (Inflexal V, Berna Biotech) could be administered to children with even severe egg allergy without any risk of allergic reactions, we used epicutaneous skin testing with the undiluted vaccine in 88 asthmatic children (44 with and 44 without egg allergy), none of whom had a positive response.
    They were then vaccinated with the whole dose of Inflexal V intramuscularly in a one-dose protocol, and the occurrence of any immediate or delayed adverse events were actively monitored for 28 days.
    The results showed the safety of the administration, and demonstrated that Inflexal V can be safely given without performing a vaccine skin test in children with any kind of egg allergy.

    PMID: 18639601 [PubMed - as supplied by publisher]
    (1.11): Vaccine. 2008 May 2;26(19):2378-88. Epub 2008 Mar 27.

    Safety and reactogenicity profile of an adjuvanted H5N1 pandemic candidate vaccine in adults within a phase III safety trial.

    R?mke HC, Bayas JM, de Juanes JR, Caso C, Richardus JH, Campins M, Rombo L, Duval X, Romanenko V, Schwarz TF, Fassakhov R, Abad-Santos F, von Sonnenburg F, Dram? M, S?nger R, Ballou WR. - VAXINOSTICS BV, University Vaccine Center Rotterdam Nijmegen, Beursplein 37, PO Box 30142, 3001 DC Rotterdam, The Netherlands.

    A multicentre, randomized, phase III clinical trial in 5071 healthy adults was conducted to evaluate the safety and reactogenicity of a 15 microg HA dose of a candidate oil-in-water emulsion-based adjuvant system (AS)-adjuvanted split-virion H5N1 (AS-H5N1) vaccine compared to a licensed seasonal influenza vaccine, Fluarix.(1)
    Stringent criteria were used to evaluate adverse events and reactogenicity profile.
    Overall, 96.7% of the 5071 vaccinated subjects completed the study.
    Significantly more participants in the AS-H5N1 vaccine group reported general or local adverse events.
    Pain was the most common symptom in both treatment groups.
    Less than 1% of subjects withdrew from the study due to adverse events and no withdrawals were due to serious adverse events related to vaccination.
    The safety and reactogenicity profile of the AS-H5N1 candidate vaccine can be considered clinically acceptable in the context of its use against pandemic influenza.

    PMID: 18407382 [PubMed - indexed for MEDLINE]

  • #2
    Re: _|selected Research Articles Abstracts, July 27, 2008|_

    > Simultaneously subtyping of all influenza A viruses using DNA microarrays.
    when available, how expensive ?

    > long-term incidence of influenza A could decrease by 11-21% in the overall population
    > by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through
    > targeting those aged 6 to <60 months and 6 months to 16 years, respectively.
    > The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively.
    "could" ?
    We do see no considerable effect yet.
    Once it works in a study, in a country I'll believe it.

    > Significantly more participants in the AS-H5N1 vaccine group reported general or local adverse events.
    my subjective estimate from the context for "significantly more" is 100%
    I'm interested in expert panflu damage estimates
    my current links: ILI-charts:


    • #3
      Re: _|selected Research Articles Abstracts, July 27, 2008|_

      flu-related articles from EID:
      Volume 14, Number 8,
      August 2008, now available on the Web.

      Bacterial Pneumonia and Pandemic Influenza Planning, R.K.
      Gupta et al.

      Deaths from Bacterial Pneumonia during 1918-19 Influenza
      Pandemic, J.F. Brundage and G.D. Shanks

      Highly Pathogenic Avian Influenza Virus (H5N1) in
      Experimentally Infected Adult Mute Swans, D. Kalthoff et al.

      Oseltamivir Prescribing, United States, 2004-2005, J.R.
      Ortiz et al.

      Virus Transfer from Personal Protective Equipment to
      Healthcare Employees, L. Casanova et al.

      Environmental Contamination during Influenza A Virus (H5N1)
      Outbreaks, Cambodia, 2006, S. Vong et al.

      Rarity of Influenza A in Spring Shorebirds, Alaska, K.
      Winker et al.
      I'm interested in expert panflu damage estimates
      my current links: ILI-charts:


      • #4
        Re: _|selected Research Articles Abstracts, July 27, 2008|_
        Avian Influenza H6 Viruses Productively Infect and Cause Illness in Mice and Ferrets.
        [yet no human H6 yet. So should we care about H5 ?]
        Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses
        [... is an important task. But does the article contribute to its solution ?]
        NEW technologies for meeting the global demand for pandemic influenza vaccines.
        [... using egg-based technologies... could help meet the global demand for pandemic vaccines...]
        Serum antibody, effector, and memory B-cell responses were greater in
        trivalent inactivated influenza vaccine (TIV) recipients than
        live attenuated influenza vaccine (LAIV) recipients
        Prior year TIV recipients had lower HAI response after vaccination with either TIV or LAIV
        and lower IgA ASC response after vaccination with TIV than prior year LAIV or no vaccination recipients
        [should we alternate TIV and LAIV vaccinations yearly ?]

        Broad influenza-specific CD8+ T cell responses in humanized mice vaccinated with influenza virus vaccines.

        Benefits of examining influenza vaccine associations outside of influenza season.

        Influenza viruses and the NF-kappaB signaling pathway - towards a novel concept of antiviral therapy.

        Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults.

        Genetic characterization of avian influenza viruses isolated in Israel during 2000-2006

        Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.

        Planning for an Influenza Pandemic: Thinking beyond the Virus.
        I'm interested in expert panflu damage estimates
        my current links: ILI-charts:


        • #5
          Re: _|selected Research Articles Abstracts, July 27, 2008|_

          pandemic poll

          human with swine flu
          I'm interested in expert panflu damage estimates
          my current links: ILI-charts:


          • #6
            Re: _|selected Research Articles Abstracts, July 27, 2008|_

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            Murakami S, Horimoto T, Mai LQ, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y.

            Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells.
            J Virol. 2008 Sep 3. [Epub ahead of print]
            PMID: 18768983 [PubMed - as supplied by publisher]
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            Hai R, Mart?nez-Sobrido L, Fraser KA, Ayllon J, Garc?a-Sastre A, Palese P.

            Influenza B NS1 Truncation Mutant Viruses: A Live-attenuated Vaccine Approach.
            J Virol. 2008 Sep 3. [Epub ahead of print]
            PMID: 18768976 [PubMed - as supplied by publisher]
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            Droebner K, Reiling SJ, Planz O.

            Role of hypercytokinemia in NF-{kappa}B p50 deficient mice after H5N1 influenza A virus infection.
            J Virol. 2008 Sep 3. [Epub ahead of print]
            PMID: 18768968 [PubMed - as supplied by publisher]
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            van der Vries E, van den Berg B, Schutten M.

            Fatal oseltamivir-resistant influenza virus infection.
            N Engl J Med. 2008 Sep 4;359(10):1074-6. No abstract available.
            PMID: 18768958 [PubMed - in process]
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            Carragher DM, Kaminski DA, Moquin A, Hartson L, Randall TD.

            A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus.
            J Immunol. 2008 Sep 15;181(6):4168-76.
            PMID: 18768874 [PubMed - in process]
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            Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Louie JK, Glaser CA, Yagi S, Schnurr DP, Haggerty TD, Parsonnet J, Ganem D, Derisi JL.

            Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections.
            Proc Natl Acad Sci U S A. 2008 Sep 3. [Epub ahead of print]
            PMID: 18768820 [PubMed - as supplied by publisher]
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            Chan W, Zhou H, Kemble G, Jin H.

            The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature.
            Virology. 2008 Sep 1. [Epub ahead of print]
            PMID: 18768193 [PubMed - as supplied by publisher]
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            Inaba H, Nishiura H.

            The state-reproduction number for a multistate class age structured epidemic system and its application to the asymptomatic transmission model.
            Math Biosci. 2008 Aug 17. [Epub ahead of print]
            PMID: 18768142 [PubMed - as supplied by publisher]
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            Lasser KE, Kelly B, Maier J, Murillo J, Hoover S, Isenberg KB, Osber D, Pilkauskas N, Willis BC, Hersey J.

            Discussions about preventive services: a qualitative study.
            BMC Fam Pract. 2008 Sep 3;9(1):49. [Epub ahead of print]
            PMID: 18768086 [PubMed - as supplied by publisher]
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            Dalton CB, Durrheim DN, Conroy MA.

            Likely impact of school and childcare closures on public health workforce during an influenza pandemic: a survey.
            Commun Dis Intell. 2008 Jun;32(2):261-2.
            PMID: 18767427 [PubMed - in process]
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            Owen R, Barr IG, Pengilley A, Liu C, Paterson B, Kaczmarek M; National Influenza Surveillance Scheme.

            Annual report of the National Influenza Surveillance Scheme, 2007.
            Commun Dis Intell. 2008 Jun;32(2):208-26.
            PMID: 18767420 [PubMed - in process]
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            Maffey AF, Venialgo CM, Barrero PR, Fuse VA, M?rques Mde L, Saia M, Villalba A, Teper AM, Mistchenko AS.

            [New respiratory viruses in children 2 months to 3 years old with recurrent wheeze]
            Arch Argent Pediatr. 2008 Aug;106(4):302-9. Spanish.
            PMID: 18766276 [PubMed - in process]
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            Chen MW, Cheng TJ, Huang Y, Jan JT, Ma SH, Yu AL, Wong CH, Ho DD.

            A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.
            Proc Natl Acad Sci U S A. 2008 Sep 2. [Epub ahead of print]
            PMID: 18765801 [PubMed - as supplied by publisher]
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            Brenner M, Oakley C, Lewis D.

            The evaluation of children and adolescents with headache.
            Curr Pain Headache Rep. 2008 Oct;12(5):361-6.
            PMID: 18765142 [PubMed - in process]
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            Weber TP, Stilianakis NI.

            A Note on the Inactivation of Influenza A Viruses By Solar Radiation, Relative Humidity and Temperature.
            Photochem Photobiol. 2008 Aug 22. [Epub ahead of print]
            PMID: 18764908 [PubMed - as supplied by publisher]
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            Sagripanti JL, David Lytle C.

            Response to Comments by Weber and Stilianakis on our Article Entitled, "Inactivation of Influenza Virus by Solar Radiation"
            Photochem Photobiol. 2008 Aug 22. [Epub ahead of print] No abstract available.
            PMID: 18764903 [PubMed - as supplied by publisher]
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            De Clercq E.

            Emerging antiviral drugs.
            Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416.
            PMID: 18764719 [PubMed - in process]
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            Del Pozo JL.

            Update and actual trends on bacterial infections following liver transplantation.
            World J Gastroenterol. 2008 Aug 28;14(32):4977-83.
            PMID: 18763277 [PubMed - in process]
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            Moore KM, Duddy A, Braun MM, Platt R, Brown JS.

            Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event detection: a survey of health plans.
            Pharmacoepidemiol Drug Saf. 2008 Sep 2. [Epub ahead of print]
            PMID: 18763248 [PubMed - as supplied by publisher]
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            Kroneman M, Paget WJ, Meuwissen LE, Joseph C, Kennedy H.

            An approach to monitoring influenza vaccination uptake across Europe.
            Euro Surveill. 2008 May 15;13(20). pii: 18874.
            PMID: 18761972 [PubMed - in process]
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            Flamand C, Larrieu S, Couvy F, Jouves B, Josseran L, Filleul L.

            Validation of a syndromic surveillance system using a general practitioner house calls network, Bordeaux, France.
            Euro Surveill. 2008 Jun 19;13(25). pii: 18905.
            PMID: 18761939 [PubMed - in process]
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            Hadzhiolova T, Pavlova S, Kotseva R.

            Laboratory investigation of the first suspected human cases of infection with avian influenza A(H5N1) virus in Bulgaria.
            Euro Surveill. 2008 Jul 24;13(30). pii: 18938.
            PMID: 18761909 [PubMed - in process]
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            Arkema JM, Meijer A, Meerhoff TJ, Van Der Velden J, Paget WJ; European Influenza Surveillance Scheme (EISS).

            Epidemiological and virological assessment of influenza activity in Europe, during the 2006-2007 winter.
            Euro Surveill. 2008 Aug 21;13(34). pii: 18958.
            PMID: 18761888 [PubMed - in process]
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            Hu AY, Weng TC, Tseng YF, Chen YS, Wu CH, Hsiao S, Chou AH, Chao HJ, Gu A, Wu SC, Chong P, Lee MS.

            Microcarrier-based MDCK cell culture system for the production of influenza H5N1 vaccines.
            Vaccine. 2008 Aug 28. [Epub ahead of print]
            PMID: 18761387 [PubMed - as supplied by publisher]
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            Moore C, Corden S, Sinha J, Jones R.

            Dry cotton or flocked respiratory swabs as a simple collection technique for the molecular detection of respiratory viruses using real-time NASBA.
            J Virol Methods. 2008 Aug 28. [Epub ahead of print]
            PMID: 18761378 [PubMed - as supplied by publisher]
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            Abramson ZH, Levi O.

            Is performance of influenza vaccination in the elderly related to treating physician's self Immunization and other physician characteristics?
            Prev Med. 2008 Aug 13. [Epub ahead of print]
            PMID: 18761366 [PubMed - as supplied by publisher]
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            van Wyk BE, Albrecht C.

            A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae).
            J Ethnopharmacol. 2008 Aug 9. [Epub ahead of print]
            PMID: 18761068 [PubMed - as supplied by publisher]
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            Miller A, Center RJ, Stambas J, Deliyannis G, Doherty PC, Howard JL, Turner SJ, Purcell DF.

            Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination.
            Vaccine. 2008 Aug 27. [Epub ahead of print]
            PMID: 18761047 [PubMed - as supplied by publisher]
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            Perron H, Mekaoui L, Bernard C, Veas F, Stefas I, Leboyer M.

            Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients.
            Biol Psychiatry. 2008 Aug 28. [Epub ahead of print]
            PMID: 18760403 [PubMed - as supplied by publisher]
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            Jang H, Boltz DA, Webster RG, Smeyne RJ.

            Viral parkinsonism.
            Biochim Biophys Acta. 2008 Aug 12. [Epub ahead of print]
            PMID: 18760350 [PubMed - as supplied by publisher]
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            Yang SY, Chieh JJ, Wang WC, Yu CY, Lan CB, Chen JH, Horng HE, Hong CY, Yang HC, Huang W.

            Ultra-highly sensitive and wash-free bio-detection of H5N1 virus by immunomagnetic reduction assays.
            J Virol Methods. 2008 Aug 26. [Epub ahead of print]
            PMID: 18760307 [PubMed - as supplied by publisher]
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            Doshi P.

            Popular and scientific attitudes regarding pandemic influenza.
            Emerg Infect Dis. 2008 Sep;14(9):1501-2; author reply 1502. No abstract available.
            PMID: 18760037 [PubMed - in process]
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            Newman AP, Reisdorf E, Beinemann J, Uyeki TM, Balish A, Shu B, Lindstrom S, Achenbach J, Smith C, Davis JP.

            Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin.
            Emerg Infect Dis. 2008 Sep;14(9):1470-2.
            PMID: 18760023 [PubMed - in process]
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            Leslie T, Billaud J, Mofleh J, Mustafa L, Yingst S.

            Knowledge, attitudes, and practices regarding avian influenza (H5N1), Afghanistan.
            Emerg Infect Dis. 2008 Sep;14(9):1459-61.
            PMID: 18760020 [PubMed - in process]
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            Uchida Y, Mase M, Yoneda K, Kimura A, Obara T, Kumagai S, Saito T, Yamamoto Y, Nakamura K, Tsukamoto K, Yamaguchi S.

            Highly pathogenic avian influenza virus (H5N1) isolated from whooper swans, Japan.
            Emerg Infect Dis. 2008 Sep;14(9):1427-9.
            PMID: 18760011 [PubMed - in process]
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            Badiaga S, Raoult D, Brouqui P.

            Preventing and controlling emerging and reemerging transmissible diseases in the homeless.
            Emerg Infect Dis. 2008 Sep;14(9):1353-9.
            PMID: 18760000 [PubMed - in process]
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            [No authors listed]

            [Efficacy of ozeltamivir (Tamiflu) in adult influenza on the epidemic rise of morbidity in Russia in the 2006-2007 season]
            Vopr Virusol. 2008 Jul-Aug;53(4):23-6. Russian.
            PMID: 18756812 [PubMed - in process]
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            [No authors listed]

            [Interpretation of the epizootic outbreak among wild and domestic birds in the south of the European part of Russia in December 2007]
            Vopr Virusol. 2008 Jul-Aug;53(4):18-23. Russian.
            PMID: 18756811 [PubMed - in process]
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            [No authors listed]

            [Epidemic strains influenza viruses A and B in the 2005-2006 season in Russia]
            Vopr Virusol. 2008 Jul-Aug;53(4):13-8. Russian.
            PMID: 18756810 [PubMed - in process]
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            Gerard MN, Trick WE, Das K, Charles-Damte M, Murphy GA, Benson IM.

            Use of Clinical Decision Support to Increase Influenza Vaccination: Multi-year Evolution of the System.
            J Am Med Inform Assoc. 2008 Aug 28. [Epub ahead of print]
            PMID: 18756001 [PubMed - as supplied by publisher]
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            Shi L, Smith SE, Malkova N, Tse D, Su Y, Patterson PH.

            Activation of the maternal immune system alters cerebellar development in the offspring.
            Brain Behav Immun. 2008 Aug 9. [Epub ahead of print]
            PMID: 18755264 [PubMed - as supplied by publisher]
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            Yamazaki Y, Ishii T, Honda A.

            The influence of oseltamivir carboxylate and oseltamivir on hemagglutinin inhibition and microneutralization test.
            Antiviral Res. 2008 Aug 26. [Epub ahead of print]
            PMID: 18755222 [PubMed - as supplied by publisher]
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            Smith AG, Sheridan PA, Tseng RJ, Sheridan JF, Beck MA.

            Selective impairment in dendritic cell function and altered antigen-specific CD8(+) T-cell responses in diet-induced obese mice infected with influenza virus.
            Immunology. 2008 Aug 27. [Epub ahead of print]
            PMID: 18754811 [PubMed - as supplied by publisher]
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            Babcock HM, Merz LR, Dubberke ER, Fraser VJ.

            Case-Control Study of Clinical Features of Influenza in Hospitalized Patients.
            Infect Control Hosp Epidemiol. 2008 Aug 28. [Epub ahead of print]
            PMID: 18754739 [PubMed - as supplied by publisher]
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            Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, Degrado WF, Howard KP.

            pH-Induced Conformational Change of the Influenza M2 Protein C-Terminal Domain.
            Biochemistry. 2008 Aug 29. [Epub ahead of print]
            PMID: 18754675 [PubMed - as supplied by publisher]
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            Zhao ZM, Shortridge KF, Garcia M, Guan Y, Wan XF.

            Genotypic diversity of H5N1 highly pathogenic avian influenza viruses.
            J Gen Virol. 2008 Sep;89(Pt 9):2182-93.
            PMID: 18753228 [PubMed - in process]
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            Ou CQ, Deng ZH, Yang L, Chen PY.

            [Effect of influenza-like diseases on the number of outpatient visits.]
            Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1446-8. Chinese.
            PMID: 18753083 [PubMed - in process]
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            Kalbfuss B, Flockerzi D, Seidel-Morgenstern A, Reichl U.

            Size-exclusion chromatography as a linear transfer system: Purification of human influenza virus as an example.
            J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):102-12. Epub 2008 Aug 12.
            PMID: 18753016 [PubMed - in process]
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            Chong KT, Thangavel RR, Tang X.

            Enhanced expression of murine beta-defensins (MBD-1, -2,- 3, and -4) in upper and lower airway mucosa of influenza virus infected mice.
            Virology. 2008 Aug 26. [Epub ahead of print]
            PMID: 18752820 [PubMed - as supplied by publisher]
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            Ritz BW.

            Supplementation with active hexose correlated compound increases survival following infectious challenge in mice.
            Nutr Rev. 2008 Sep;66(9):526-31.
            PMID: 18752476 [PubMed - in process]
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            Keitel WA, Atmar RL, Nino D, Cate TR, Couch RB.

            Increasing Doses of an Inactivated Influenza A/H1N1 Vaccine Induce Increasing Levels of Cross-Reacting Antibody to Subsequent, Antigenically Different, Variants.
            J Infect Dis. 2008 Oct 1;198(7):1016-8.
            PMID: 18729777 [PubMed - in process]
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            Kuerten S, Asaad RJ, Schoenberger SP, Angelov DN, Lehmann PV, Tary-Lehmann M.

            The TRAIL of Helpless CD8(+) T Cells in HIV Infection.
            AIDS Res Hum Retroviruses. 2008 Aug 26. [Epub ahead of print]
            PMID: 18729775 [PubMed - as supplied by publisher]
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            Pi?ol-Ripoll G, de la Puerta I, Santos S, Purroy F, Mostacero E.

            Chronic Bronchitis and Acute Infections as New Risk Factors for Ischemic Stroke and the Lack of Protection Offered by the Influenza Vaccination.
            Cerebrovasc Dis. 2008 Aug 27;26(4):339-347. [Epub ahead of print]
            PMID: 18728360 [PubMed - as supplied by publisher]
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            Iriso R, Ocakacon R, Acayo JA, Mawanda MA, Kisayke A.

            Bacterial meningitis following introduction of Hib conjugate vaccine in northern Uganda.
            Ann Trop Paediatr. 2008 Sep;28(3):211-6.
            PMID: 18727850 [PubMed - in process]
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            De Clercq E, Field HJ.

            Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2008 (2nd edition): RNA viruses.
            Antivir Chem Chemother. 2008;19(2):63-74.
            PMID: 18727441 [PubMed - in process]
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            Sands BE.

            Response to letter by Field et al, "influenza vaccinations: Should they really be encouraged for IBD patients being treated with immunosuppressives?"
            Inflamm Bowel Dis. 2008 Aug 25. [Epub ahead of print] No abstract available.
            PMID: 18727073 [PubMed - as supplied by publisher]
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            Peddecord KM, Jacobson IG, Engelberg M, Kwizera L, Macias V, Gustafson KW.

            Can movie theater advertisements promote health behaviors? Evaluation of a flu vaccination pilot campaign.
            J Health Commun. 2008 Sep;13(6):596-613.
            PMID: 18726815 [PubMed - in process]
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            Otvos L Jr.

            Synthesis of a multivalent, multiepitope vaccine construct.
            Methods Mol Biol. 2008;494:263-73.
            PMID: 18726579 [PubMed - in process]
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            Tian P, Ren S, Ren C, Teng Q, Qu S, Yao M, Gu J.

            A novel receptor-targeted gene delivery system for cancer gene therapy.
            Sci China C Life Sci. 1999 Apr;42(2):216-24.
            PMID: 18726476 [PubMed - in process]
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            Wu Q, Chen W, Wu J.

            Effect of mouse thymic medullary epithelial cell line on thymocyte development and functional maturationin vivo.
            Sci China C Life Sci. 1998 Apr;41(2):203-8.
            PMID: 18726207 [PubMed - in process]
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            Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F, Leung FC.

            Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia.
            PLoS Pathog. 2008 Aug 22;4(8):e1000130.
            PMID: 18725937 [PubMed - in process]
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            Nelson MI, Edelman L, Spiro DJ, Boyne AR, Bera J, Halpin R, Ghedin E, Miller MA, Simonsen L, Viboud C, Holmes EC.

            Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
            PLoS Pathog. 2008 Aug 22;4(8):e1000133.
            PMID: 18725925 [PubMed - in process]
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            Das K, Ma LC, Xiao R, Radvansky B, Aramini J, Zhao L, Marklund J, Kuo RL, Twu KY, Arnold E, Krug RM, Montelione GT.

            Structural basis for suppression of a host antiviral response by influenza A virus.
            Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13093-8. Epub 2008 Aug 25.
            PMID: 18725644 [PubMed - in process]
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            Ilyushina NA, Hay A, Yilmaz N, Boon AC, Webster RG, Govorkova EA.

            Oseltamivir-Ribavirin Combination Therapy for Highly Pathogenic H5N1 Influenza Virus Infection in Mice.
            Antimicrob Agents Chemother. 2008 Aug 25. [Epub ahead of print]
            PMID: 18725448 [PubMed - as supplied by publisher]
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            Lambert SB, Whiley DM, O'Neill NT, Andrews EC, Canavan FM, Bletchly C, Siebert DJ, Sloots TP, Nissen MD.

            Comparing nose-throat swabs and nasopharyngeal aspirates collected from children with symptoms for respiratory virus identification using real-time polymerase chain reaction.
            Pediatrics. 2008 Sep;122(3):e615-20. Epub 2008 Aug 25.
            PMID: 18725388 [PubMed - in process]
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            Groenwold RH, Hoes AW, Nichol KL, Hak E.

            Quantifying the potential role of unmeasured confounders: the example of influenza vaccination.
            Int J Epidemiol. 2008 Aug 25. [Epub ahead of print]
            PMID: 18725358 [PubMed - as supplied by publisher]
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            Duwe S, Schweiger B.

            A new and rapid genotypic assay for the detection of neuraminidase inhibitor resistant influenza A viruses of subtype H1N1, H3N2, and H5N1.
            J Virol Methods. 2008 Aug 22. [Epub ahead of print]
            PMID: 18725246 [PubMed - as supplied by publisher]
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            Peng Y, Zhou H, Li C, Jin M.

            [The rescue of H1N1 subtype swine influenza virus]
            Sheng Wu Gong Cheng Xue Bao. 2008 May;24(5):857-61. Chinese.
            PMID: 18724708 [PubMed - in process]
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            Ljungman P, Avetisyan G.

            Influenza vaccination in hematopoietic SCT recipients.
            Bone Marrow Transplant. 2008 Aug 25. [Epub ahead of print]
            PMID: 18724396 [PubMed - as supplied by publisher]
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            Bai A, Higham E, Eisen HN, Wittrup KD, Chen J.

            Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
            Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13003-8. Epub 2008 Aug 22.
            PMID: 18723683 [PubMed - in process]
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            Couzigou C, Voyer C, Shaghaghi CK, Bour?e P, Vittecoq D.

            [Vaccinations of HIV-infected travelers.]
            Med Mal Infect. 2008 Aug 22. [Epub ahead of print] French.
            PMID: 18723304 [PubMed - as supplied by publisher]
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            Biswas PK, Barua H, Uddin GM, Biswas D, Ahad A, Debnath NC.

            Serosurvey of five viruses in chickens on smallholdings in Bangladesh.
            Prev Vet Med. 2008 Aug 22. [Epub ahead of print]
            PMID: 18723236 [PubMed - as supplied by publisher]
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            Sironi L, Williams JL, Moreno-Martin AM, Ramelli P, Stella A, Jianlin H, Weigend S, Lombardi G, Cordioli P, Mariani P.

            Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631.
            Virology. 2008 Aug 22. [Epub ahead of print]
            PMID: 18723201 [PubMed - as supplied by publisher]
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            James CM, Foong YY, Mansfield JP, Vind AR, Fenwick SG, Ellis TM.

            Evaluation of a positive marker of avian influenza vaccination in ducks for use in H5N1 surveillance.
            Vaccine. 2008 Aug 22. [Epub ahead of print]
            PMID: 18723069 [PubMed - as supplied by publisher]
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            Musonda P, Hocine MN, Andrews NJ, Tubert-Bitter P, Farrington CP.

            Monitoring vaccine safety using case series cumulative sum charts.
            Vaccine. 2008 Aug 22. [Epub ahead of print]
            PMID: 18723063 [PubMed - as supplied by publisher]
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            Brincks EL, Kucaba TA, Legge KL, Griffith TS.

            Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells.
            Hum Immunol. 2008 Aug 21. [Epub ahead of print]
            PMID: 18723061 [PubMed - as supplied by publisher]
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            Perronne C.

            [Current data on vaccines for respiratory diseases.]
            Med Mal Infect. 2008 Aug 21. [Epub ahead of print] French.
            PMID: 18722726 [PubMed - as supplied by publisher]
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            van Delden JJ, Ashcroft R, Dawson A, Marckmann G, Upshur R, Verweij MF.

            The ethics of mandatory vaccination against influenza for health care workers.
            Vaccine. 2008 Aug 20. [Epub ahead of print]
            PMID: 18722495 [PubMed - as supplied by publisher]
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            Jansen AG, Sanders EA, Nichol KL, van Loon AM, Hoes AW, Hak E.

            Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program.
            Vaccine. 2008 Aug 20. [Epub ahead of print]
            PMID: 18722492 [PubMed - as supplied by publisher]
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            Wang W, Butler EN, Veguilla V, Vassell R, Terrig Thomas J, Moos M Jr, Ye Z, Hancock K, Weiss CD.

            Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies.
            J Virol Methods. 2008 Sep 3. [Epub ahead of print]
            PMID: 18722473 [PubMed - as supplied by publisher]
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            Burstein JL.

            Smoke and shadows: measuring hospital disaster preparedness.
            Ann Emerg Med. 2008 Sep;52(3):230-1. No abstract available.
            PMID: 18722247 [PubMed - indexed for MEDLINE]
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            He CQ, Han GZ, Wang D, Liu W, Li GR, Liu XP, Ding NZ.

            Homologous recombination evidence in human and swine influenza A viruses.
            Virology. 2008 Aug 20. [Epub ahead of print]
            PMID: 18721995 [PubMed - as supplied by publisher]
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            Murris-Espin M, Aubert M, Bosdure E, Dubus JC.

            Influenza vaccination coverage in patients with cystic fibrosis followed at 12 care centers in the Greater South Region of France for the season 2005/2006.
            Vaccine. 2008 Aug 19. [Epub ahead of print]
            PMID: 18721838 [PubMed - as supplied by publisher]
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            Tang Y, Wu P, Peng D, Long J, Zhang P, Zhang W, Li Y, Wang W, Liu X.

            [Virulence changes of H5N1 avian influenza virus after gene reassortment]
            Wei Sheng Wu Xue Bao. 2008 Jun 4;48(6):745-9. Chinese.
            PMID: 18720838 [PubMed - in process]
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            Inglis S, Wood J, Minor P.

            Open debate could slow flu vaccine production.
            Nature. 2008 Aug 21;454(7207):939. No abstract available.
            PMID: 18719565 [PubMed - indexed for MEDLINE]
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            [No authors listed]

            Influenza-associated encephalopathy.
            Arch Dis Child. 2008 Sep;93(9):777. No abstract available.
            PMID: 18719160 [PubMed - as supplied by publisher]
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            Carr MJ, Sayre N, Duffy M, Connell J, Hall WW.

            Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses.
            J Virol Methods. 2008 Sep 2. [Epub ahead of print]
            PMID: 18718489 [PubMed - as supplied by publisher]
            Related Articles, Links
            Hengst M, H?usler M, Honnef D, Scheithauer S, Ritter K, Kleines M.

            [Human Bocavirus-Infection (HBoV): An Important Cause of Severe Viral Obstructive Bronchitis in Children.]
            Klin Padiatr. 2008 Sep-Oct;220(5):296-301. German.
            PMID: 18716982 [PubMed - in process]
            Related Articles, Links
            Merrick EL, Hodgkin D, Garnick DW, Horgan CM, Panas L, Ryan M, Saitz R, Blow FC.

            Unhealthy Drinking Patterns and Receipt of Preventive Medical Services by Older Adults.
            J Gen Intern Med. 2008 Aug 21. [Epub ahead of print]
            PMID: 18716847 [PubMed - as supplied by publisher]
            Related Articles, Links
            Yu H, Gao Z, Feng Z, Shu Y, Xiang N, Zhou L, Huai Y, Feng L, Peng Z, Li Z, Xu C, Li J, Hu C, Li Q, Xu X, Liu X, Liu Z, Xu L, Chen Y, Luo H, Wei L, Zhang X, Xin J, Guo J, Wang Q, Yuan Z, Zhou L, Zhang K, Zhang W, Yang J, Zhong X, Xia S, Li L, Cheng J, Ma E, He P, Lee SS, Wang Y, Uyeki TM, Yang W.

            Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China.
            PLoS ONE. 2008 Aug 21;3(8):e2985.
            PMID: 18716658 [PubMed - in process]
            Related Articles, Links
            Yu X, Tsibane T, McGraw PA, House FS, Keefer CJ, Hicar MD, Tumpey TM, Pappas C, Perrone LA, Martinez O, Stevens J, Wilson IA, Aguilar PV, Altschuler EL, Basler CF, Jr JE.

            Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.
            Nature. 2008 Aug 17. [Epub ahead of print]
            PMID: 18716625 [PubMed - as supplied by publisher]
            I'm interested in expert panflu damage estimates
            my current links: ILI-charts:


            • #7
              Re: _|selected Research Articles Abstracts, July 27, 2008|_

              now I have 15000 of the ~47000 , years 2003-2008 [452K compressed, 1371K expanded]

              I also have these with authors and dates and journals, but some of the long lines are mangled. [~4MB]
              I have it not yet with links to the abstracts

              the whole list with headlines and links is ~8MB
              with headlines,hyperlinks,authors,journals probably ~15M

              Ideally new updates of article-headlines should be posted as soon as they appear.
              I don't know, how frequently this is updated at pubmed.

              I try to post them here
              but could need help, when I forget an update

              And then, I think we should have short summaries of the abstracts, but didn't find
              many summaries on the web.

              downloading and generating a html-file with titles,authors,journals,hyperlinks to abstracts
              will probably take me hours.
              You can still have it at pubmed, but on >1300 pages :-(

              year, articles
              1994 ,3
              1997 ,6
              1998 ,15
              1999 ,16
              2000 ,21
              2001 ,15
              2002 ,11
              2003 ,539
              2004 ,1798
              2005 ,2074
              2006 ,2944
              2007 ,2613
              2008 ,2029
              I'm interested in expert panflu damage estimates
              my current links: ILI-charts:


              • #8
                Re: _|selected Research Articles Abstracts, July 27, 2008|_



                Pandemic Influenza and Excess Intensive-Care Workload, R.E.
                Nap et al.

                CME Activity:
                Microbial Interactions during Upper Respiratory Tract
                Infections, M.M. Pettigrew et al.


                Automatic Outbreak Detection Algorithm versus Electronic
                Reporting System, M. Straetemans et al.

                Influenza A Virus Infections in Land Birds, People's Republic
                of China, A.T. Peterson et al.

                Effects of School Closures, 2008 Influenza Season, Hong Kong,
                B.J. Cowling et al.


                Avian Influenza Virus (H5N1) in Domestic Duck Feathers, Y.
                Yamamoto et al.

                Resource Allocation during an Influenza Pandemic (response)
                I'm interested in expert panflu damage estimates
                my current links: ILI-charts:


                • #9
                  Re: _|selected Research Articles Abstracts, July 27, 2008|_

                  Items 1 - 20 of 47407Page of 2371Next

                  1: Dinapoli JM, Murphy BR, Collins PL, Bukreyev A.
                  Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection.
                  Virol J. 2008 Sep 24;5(1):105. [Epub ahead of print]
                  PMID: 18816384 [PubMed - as supplied by publisher]

                  2: Morrissey B, Downard KM.
                  Kinetics of Antigen-Antibody Interactions Employing a MALDI Mass Spectrometry Immunoassay.
                  Anal Chem. 2008 Sep 25. [Epub ahead of print]
                  PMID: 18816071 [PubMed - as supplied by publisher]

                  3: Li C, Hatta M, Watanabe S, Neumann G, Kawaoka Y.
                  Compatibility among polymerase subunit proteins is a restricting factor in the reassortment between equine H7N7 and human H3N2 viruses.
                  J Virol. 2008 Sep 24. [Epub ahead of print]
                  PMID: 18815312 [PubMed - as supplied by publisher]

                  4: Hutchinson EC, Curran MD, Read EK, Gog JR, Digard P.
                  Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus.
                  J Virol. 2008 Sep 24. [Epub ahead of print]
                  PMID: 18815307 [PubMed - as supplied by publisher]

                  5: Wisnivesky JP, Lorenzo J, Lyn-Cook R, Newman T, Aponte A, Kiefer E, Halm EA.
                  Barriers to adherence to asthma management guidelines among inner-city primary care providers.
                  Ann Allergy Asthma Immunol. 2008 Sep;101(3):264-70.
                  PMID: 18814449 [PubMed - in process]

                  6: Tang JW, Ngai KL, Chan PK.
                  Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans.
                  J Med Virol. 2008 Sep 23;80(11):1992-1996. [Epub ahead of print]
                  PMID: 18814271 [PubMed - as supplied by publisher]

                  7: Shen S, Mahadevappa G, Oh HL, Wee BY, Choi YW, Hwang LA, Lim SG, Hong W, Lal SK, Tan YJ.
                  Comparing the antibody responses against recombinant hemagglutinin proteins of avian influenza A (H5N1) virus expressed in insect cells and bacteria.
                  J Med Virol. 2008 Sep 23;80(11):1972-1983. [Epub ahead of print]
                  PMID: 18814259 [PubMed - as supplied by publisher]

                  8: Pariani E, Amendola A, Zappa A, Bianchi S, Colzani D, Anselmi G, Zanetti A, Tanzi E.
                  Molecular characterization of influenza viruses circulating in Northern Italy during two seasons (2005/2006 and 2006/2007) of low influenza activity.
                  J Med Virol. 2008 Sep 23;80(11):1984-1991. [Epub ahead of print]
                  PMID: 18814246 [PubMed - as supplied by publisher]

                  9: Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH.
                  Antiviral effects of ascorbic and dehydroascorbic acids in vitro.
                  Int J Mol Med. 2008 Oct;22(4):541-5.
                  PMID: 18813862 [PubMed - in process]

                  10: Reis PO, Nozawa MR.
                  [Analysis of seniors vaccination programme in Campinas, S?o Paulo State, Brazil]
                  Cien Saude Colet. 2007 Sep-Oct;12(5):1353-61. Portuguese.
                  PMID: 18813470 [PubMed - in process]

                  11: Cheng A, Wong SM, Yuan YA.
                  Structural basis for dsRNA recognition by NS1 protein of influenza A virus.
                  Cell Res. 2008 Sep 23. [Epub ahead of print]
                  PMID: 18813227 [PubMed - as supplied by publisher]

                  12: Onozuka D, Hagihara A.
                  Spatial and Temporal Dynamics of Influenza Outbreaks.
                  Epidemiology. 2008 Sep 20. [Epub ahead of print]
                  PMID: 18813019 [PubMed - as supplied by publisher]

                  13: Zhou Y, Fang F, Chen J, Wang H, Chang H, Yang Z, Chen Z.
                  Electroporation at Low Voltages Enables DNA Vaccine to Provide Protection against a Lethal H5N1 Avian Influenza Virus Challenge in Mice.
                  Intervirology. 2008 Sep 24;51(4):241-246. [Epub ahead of print]
                  PMID: 18812697 [PubMed - as supplied by publisher]

                  14: Severson WE, McDowell M, Ananthan S, Chung DH, Rasmussen L, Sosa MI, White EL, Noah J, Jonsson CB.
                  High-Throughput Screening of a 100,000-Compound Library for Inhibitors of Influenza A Virus (H3N2).
                  J Biomol Screen. 2008 Sep 23. [Epub ahead of print]
                  PMID: 18812571 [PubMed - as supplied by publisher]

                  15: Zhang S, Xiao L, Zhou H, Yu Z, Chen H, Guo A, Jin M.
                  Generation and characterization of an H5N1 avian influenza virus hemagglutinin glycoprotein pseudotyped lentivirus.
                  J Virol Methods. 2008 Sep 20. [Epub ahead of print]
                  PMID: 18812190 [PubMed - as supplied by publisher]

                  16: Boden JH, Myers ML, Lee T, Bushley DM, Torres MF.
                  Effect of lidocaine gel on povidone-iodine antisepsis and microbial survival.
                  J Cataract Refract Surg. 2008 Oct;34(10):1773-5.
                  PMID: 18812132 [PubMed - in process]

                  17: Hartshorn KL, Webby R, White MR, Tecle T, Pan C, Boucher S, Moreland RJ, Crouch EC, Scheule RK.
                  Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D.
                  Respir Res. 2008 Sep 23;9(1):65. [Epub ahead of print]
                  PMID: 18811961 [PubMed - as supplied by publisher]
                  I'm interested in expert panflu damage estimates
                  my current links: ILI-charts:


                  • #10
                    Re: _|selected Research Articles Abstracts, July 27, 2008|_

                    Items 1 - 20 of 47430
                    1:Bos ME, Nielen M, Koch G, Stegeman A, De Jong MC.
                    Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys.
                    Vaccine. 2008 Sep 23. [Epub ahead of print]

                    2:Eichelberger MC, Hassantoufighi A, Wu M, Li M.
                    Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay.
                    Virol J. 2008 Sep 26;5(1):109. [Epub ahead of print]

                    3:Leon-Ponte M, Kasprzyski T, Mannik LA, Haeryfar SM.
                    Altered immunodominance hierarchies of influenza A virus-specific H-2(b)-restricted CD8+ T cells in the absence of terminal deoxynucleotidyl transferase.
                    Immunol Invest. 2008;37(7):714-25.

                    4: Kim YK, Nyambat B, Hong YS, Lee CG, Lee JW, Kilgore PE.
                    Burden of viral respiratory disease hospitalizations among children in a community of Seoul, Republic of Korea, 1995-2005.
                    Scand J Infect Dis. 2008 Sep 26:1-8. [Epub ahead of print]

                    5iederen BM, Van Der Eerden MM, Vlaspolder F, Boersma WG, Kluytmans JA, Peeters MF.
                    Detection of respiratory viruses and Legionella spp. by real-time polymerase chain reaction in patients with community acquired pneumonia.
                    Scand J Infect Dis. 2008 Sep 26:1-6. [Epub ahead of print]

                    6:Taubenberger JK.
                    Influenza hemagglutinin attachment to target cells: 'birds do it, we do it...'
                    Future Virol. 2006;1(4):415-418. No abstract available.

                    7:Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD.
                    Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy.
                    Nat Biotechnol. 2008 Sep 28. [Epub ahead of print]

                    8:Chou YT, Tam B, Linay F, Lai EC.
                    Transgenic inhibitors of RNA interference in Drosophila.
                    Fly (Austin). 2007 Nov-Dec;1(6):311-6. Epub 2007 Nov 18.

                    9avoust B, Mari? JL, Boni M.
                    [Prevention of zoonoses: creation of a unit for early detection of animal infections]
                    Bull Acad Natl Med. 2008 Mar;192(3):541-52; discussion 553-4. French.

                    10:Gilbert M, Slingenbergh J, Xiao X.
                    Climate change and avian influenza.
                    Rev Sci Tech. 2008 Aug;27(2):459-66.

                    11:[No authors listed]
                    [Situation on avian influenza caused by highly pathogenic influenza virus A/H5N1 in countries of Asia, Africa, and Europe in 2007]
                    Zh Mikrobiol Epidemiol Immunobiol. 2008 Jul-Aug;(4):37-42. Russian. No abstract available.
                    I'm interested in expert panflu damage estimates
                    my current links: ILI-charts:


                    • #11
                      Re: _|selected Research Articles Abstracts, July 27, 2008|_

                      Items 1 - 20 of 47448

                      1:Chen J, Yang Z, Chen Q, Liu X, Fang F, Chang H, Li D, Chen Z.
                      Characterization of H5N1 influenza A viruses isolated from domestic green-winged teal.
                      Virus Genes. 2008 Sep 30. [Epub ahead of print]

                      2:Vandalen KK, Anderson TD, Killian ML, Pedersen JC, Franklin AB, Piaggio AJ.
                      Increased detection of influenza A H16 in the United States.
                      Arch Virol. 2008 Sep 30. [Epub ahead of print]

                      3:Radyukhin V, Fedorova N, Ksenofontov A, Serebryakova M, Baratova L.
                      Cold co-extraction of hemagglutinin and matrix M1 protein from influenza virus A by a combination of non-ionic detergents allows for visualization of the raft-like nature of the virus envelope.
                      Arch Virol. 2008 Sep 30. [Epub ahead of print]

                      4:Li J, Cardona CJ, Xing Z, Woolcock PR.
                      Genetic and phenotypic characterization of a low-pathogenicity avian influenza H11N9 virus.
                      Arch Virol. 2008 Oct 1. [Epub ahead of print]

                      5:Camargo CA Jr, Ginde AA, Clark S, Cartwright CP, Falsey AR, Niewoehner DE.
                      Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease.
                      Intern Emerg Med. 2008 Sep 30. [Epub ahead of print]

                      6:Lurie N, Dausey DJ, Knighton T, Moore M, Zakowski S, Deyton L.
                      Community Planning for Pandemic Influenza: Lessons From the VA Health Care System.
                      Disaster Med Public Health Prep. 2008 Sep 26. [Epub ahead of print]

                      7:Conti G, Magliani W, Conti S, Nencioni L, Sgarbanti R, Palamara AT, Polonelli L.
                      Therapeutic activity of an antiidiotypic antibody-derived killer peptide against influenza A virus experimental infection.
                      Antimicrob Agents Chemother. 2008 Sep 29. [Epub ahead of print]

                      8:Powell ML, Napthine S, Jackson RJ, Brierley I, Brown TD.
                      Characterization of the termination-reinitiation strategy employed in the expression of influenza B virus BM2 protein.
                      RNA. 2008 Sep 29. [Epub ahead of print]

                      9:Alisky J.
                      Bovine and human-derived passive immunization could help slow a future avian influenza pandemic.
                      Med Hypotheses. 2008 Sep 26. [Epub ahead of print]

                      10:Ooi LS, Tian L, Su M, Ho WS, Sun SS, Chung HY, Wong HN, Ooi VE.
                      Isolation, characterization, molecular cloning and modeling of a new lipid transfer protein with antiviral and antiproliferative activities from Narcissus tazetta.
                      Peptides. 2008 Sep 9. [Epub ahead of print]

                      11:Sakudo A, Ikuta K.
                      Efficient capture of infectious H5 avian influenza virus utilizing magnetic beads coated with anionic polymer.
                      Biochem Biophys Res Commun. 2008 Sep 25. [Epub ahead of print]

                      12: Ma HY, Yang L, Zhang M, Wang CH, Wang ZT.
                      A new compound from Senecio cannabifolius var integrilifolius.
                      Yao Xue Xue Bao. 2008 Jun;43(6):626-9.

                      13:Abu Sitteh MH, Sener K, Yapar M, Kili? A, G?ney C, Kubar A.
                      [Investigation of viral nucleic acids in middle-ear effusion specimens from children with acute otitis media]
                      Mikrobiyol Bul. 2008 Jul;42(3):437-43. Turkish.

                      14:Y?ksel H, Yilmaz O, Ak?ali S, S?ğ?t A, Yilmaz Ciftdoğan D, Urk V, Ertan P, Sanlidağ T.
                      [Common viral etiologies of community acquired lower respiratory tract infections in young children and their relationship with long term complications]
                      Mikrobiyol Bul. 2008 Jul;42(3):429-35. Turkish.
                      I'm interested in expert panflu damage estimates
                      my current links: ILI-charts:


                      • #12
                        Re: _|selected Research Articles Abstracts, July 27, 2008|_


                        1: [No authors listed]
                        Influenza vaccine 2008-2009.
                        Med Lett Drugs Ther. 2008 Oct 6;50(1296):77-9.

                        2:Koskenvuo M, M?tt?nen M, Rahiala J, Saarinen-Pihkala UM, Riikonen P, Waris M, Ziegler T, Uhari M, Salmi TT, Ruuskanen O.
                        Respiratory Viral Infections in Children With Leukemia.
                        Pediatr Infect Dis J. 2008 Oct 1. [Epub ahead of print]

                        3:Wright PF, Sannella E, Shi JR, Zhu Y, Ikizler MR, Edwards KM.
                        Antibody Responses After Inactivated Influenza Vaccine in Young Children.
                        Pediatr Infect Dis J. 2008 Oct 1. [Epub ahead of print]

                        4:Heidema J, Rossen JW, Lukens MV, Ketel MS, Scheltens E, Kranendonk ME, van Maren WW, van Loon AM, Otten HG, Kimpen JL, van Bleek GM.
                        Dynamics of Human Respiratory Virus-Specific CD8+ T Cell Responses in Blood and Airways during Episodes of Common Cold.
                        J Immunol. 2008 Oct 15;181(8):5551-9.

                        5:Westendorf AM, Fleissner D, Groebe L, Jung S, Gruber AD, Hansen W, Buer J.
                        CD4+ Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells.
                        Gut. 2008 Oct 2. [Epub ahead of print]

                        6:Stech J, Stech O, Herwig A, Altmeppen H, Hundt J, Gohrbandt S, Kreibich A, Weber S, Klenk HD, Mettenleiter TC.
                        Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification.
                        Nucleic Acids Res. 2008 Oct 2. [Epub ahead of print]

                        7ale SE, Mayer C, Mayer MC, Menegus MA.
                        The Analytical and Clinical Sensitivity of the 3MTM Rapid Detection Influenza A&B Assay.
                        J Clin Microbiol. 2008 Oct 1. [Epub ahead of print]

                        8:Krause G; Working Group on Prioritisation at the Robert Koch Institute.
                        Prioritisation of infectious diseases in public health--call for comments.
                        Euro Surveill. 2008 Oct 2;13(40). pii: 18996.

                        9:Taylor MR, Agho KE, Stevens GJ, Raphael B.
                        Factors influencing psychological distress during a disease epidemic: Data from Australia's first outbreak of equine influenza.
                        BMC Public Health. 2008 Oct 3;8(1):347. [Epub ahead of print]

                        10:Fields SW, Baiocco PJ, Korelitz BI.
                        Influenza vaccinations: Should they really be encouraged for IBD patients being treated with immunosuppressives?
                        Inflamm Bowel Dis. 2008 Oct 2. [Epub ahead of print] No abstract available.

                        11:Luby SP, Brooks WA, Zaman K, Hossain S, Ahmed T.
                        Infectious diseases and vaccine sciences: strategic directions.
                        J Health Popul Nutr. 2008 Sep;26(3):295-310.

                        12:Finelli L, Fiore A, Dhara R, Brammer L, Shay DK, Kamimoto L, Fry A, Hageman J, Gorwitz R, Bresee J, Uyeki T.
                        Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection.
                        Pediatrics. 2008 Oct;122(4):805-11.

                        13:Keleta L, Ibricevic A, Bovin NV, Brody SL, Brown EG.
                        Experimental evolution of Human Influenza H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2.
                        J Virol. 2008 Oct 1. [Epub ahead of print]

                        14:Floyd DL, Ragains JR, Skehel JJ, Harrison SC, van Oijen AM.
                        Single-particle kinetics of influenza virus membrane fusion.
                        Proc Natl Acad Sci U S A. 2008 Sep 30. [Epub ahead of print]

                        15usser D.
                        [Prevention of chronic obstructive pulmonary disease exacerbations.]
                        Presse Med. 2008 Sep 29. [Epub ahead of print] French.

                        16:Sherman FT.
                        Learning to EXHALE: Don't catch the flu this season!
                        Geriatrics. 2008 Oct;63(10):2-3.

                        17:Erkoreka A.
                        Spanish influenza in the heart of Europe. A study of a significant sample of the Basque population.
                        Gesnerus. 2008;65(1-2):30-41.

                        18:Calle PP, Seagars DJ, McClave C, Senne D, House C, House JA.
                        Viral and bacterial serology of six free-ranging bearded seals Erignathus barbatus.
                        Dis Aquat Organ. 2008 Aug 19;81(1):77-80.

                        19:Bogomolni AL, Gast RJ, Ellis JC, Dennett M, Pugliares KR, Lentell BJ, Moore MJ.
                        Victims or vectors: a survey of marine vertebrate zoonoses from coastal waters of the Northwest Atlantic.
                        Dis Aquat Organ. 2008 Aug 19;81(1):13-38.

                        20:Griffin S, Stgelais C, Owsianka AM, Patel AH, Rowlands D, Harris M.
                        Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.
                        Hepatology. 2008 Jul 28. [Epub ahead of print]

                        21:Crowther BR, Schmeling TD, Hayney MS.
                        Influenza vaccination: outlook for 2008-09 season.
                        J Am Pharm Assoc (2003). 2008 Sep-Oct;48(5):686-7. No abstract available.

                        22:Phin NF, Davies L.
                        Re: Resource allocation during an influenza pandemic.
                        Emerg Infect Dis. 2008 Oct;14(10):1676; author reply 1676-7. No abstract available.

                        23:Yamamoto Y, Nakamura K, Okamatsu M, Miyazaki A, Yamada M, Mase M.
                        Detecting avian influenza virus (H5N1) in domestic duck feathers.
                        Emerg Infect Dis. 2008 Oct;14(10):1671-2. No abstract available.

                        24:Cowling BJ, Lau EH, Lam CL, Cheng CK, Kovar J, Chan KH, Peiris JS, Leung GM.
                        Effects of school closures, 2008 winter influenza season, Hong Kong.
                        Emerg Infect Dis. 2008 Oct;14(10):1660-2.

                        25:Peterson AT, Bush SE, Spackman E, Swayne DE, Ip HS.
                        Influenza A virus infections in land birds, People's Republic of China.
                        Emerg Infect Dis. 2008 Oct;14(10):1644-6.

                        26:Nap RE, Andriessen MP, Meessen NE, Miranda Ddos R, van der Werf TS.
                        Pandemic influenza and excess intensive-care workload.
                        Emerg Infect Dis. 2008 Oct;14(10):1518-25.
                        I'm interested in expert panflu damage estimates
                        my current links: ILI-charts:


                        • #13
                          Re: _|selected Research Articles Abstracts, July 27, 2008|_

                          OK, it's apparant that there is no more interest here in discussing
                          scientific papers about influenza, so I'll stop.
                          I'm interested in expert panflu damage estimates
                          my current links: ILI-charts:


                          • #14
                            Re: _|selected Research Articles Abstracts, July 27, 2008|_

                            Au contraire, GSGS!

                            I started to post research articles abstracts singularly, for a better search engine functionality.

                            You can see my posts searching with the help of 'tags' into ''search tool'', forum users' bar (just at right of red button 'latest posts').

                            I tagged all posts with both ' 'research'' and ''abstract'' for a more rapid localization.
                            I think that tracking research is important as for the news.


                            • #15
                              Re: _|selected Research Articles Abstracts, July 27, 2008|_

                              My brain and eyeballs will not cooperate when studies are posted in italics
                              The salvage of human life ought to be placed above barter and exchange ~ Louis Harris, 1918