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Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory

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  • Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory

    Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory http://ajp.amjpathol.org/cgi/content....2007.070248v1







    Tract of Humans and Other Mammals

    <nobr>Debby van Riel,</nobr> <nobr>Vincent J. Munster,</nobr> <nobr>Emmie de Wit,</nobr> <nobr>Guus F. Rimmelzwaan,</nobr> <nobr>Ron A.M. Fouchier,</nobr> <nobr>Albert D.M.E. Osterhaus,</nobr> and <nobr>Thijs Kuiken


    </nobr>
    Viral attachment to the host cell is critical for tissue and<sup> </sup>species specificity of virus infections. Recently, pattern of<sup> </sup>viral attachment (PVA) in human respiratory tract was determined<sup> </sup>for highly pathogenic avian influenza virus of subtype H5N1.<sup> </sup>However, PVA of human influenza viruses and other avian influenza<sup> </sup>viruses in either humans or experimental animals is unknown.<sup> </sup>Therefore, we compared PVA of two human influenza viruses (H1N1<sup> </sup>and H3N2) and two low pathogenic avian influenza viruses (H5N9<sup> </sup>and H6N1) with that of H5N1 virus in respiratory tract tissues<sup> </sup>of humans, mice, ferrets, cynomolgus macaques, cats, and pigs<sup> </sup>by virus histochemistry.

    We found that human influenza viruses<sup> </sup>attached more strongly to human trachea and bronchi than H5N1<sup> </sup>virus and attached to different cell types than H5N1 virus.
    <sup> </sup>These differences correspond to primary diagnoses of tracheobronchitis<sup> </sup>for human influenza viruses and diffuse alveolar damage for<sup> </sup>H5N1 virus. The PVA of low pathogenic avian influenza viruses<sup> </sup>in human respiratory tract resembled that of H5N1 virus, demonstrating<sup> </sup>that other properties determine its pathogenicity for humans.<sup> </sup>The PVA in human respiratory tract most closely mirrored that<sup> </sup>in ferrets and pigs for human influenza viruses and that in<sup> </sup>ferrets, pigs, and cats for avian influenza viruses.

  • #2
    Re: Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory

    now it would be interesting to know, what is required to change that.

    Is it just all and only the RBD of the HA ?
    Can't they reassort some of the examined viruses and examine
    how that changes the PVA ?
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

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