Announcement

Collapse
No announcement yet.

Gene . Mind the feline coronavirus: Comparison with SARS-CoV-2

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Gene . Mind the feline coronavirus: Comparison with SARS-CoV-2


    Gene


    . 2022 Mar 22;825:146443.
    doi: 10.1016/j.gene.2022.146443. Online ahead of print.
    Mind the feline coronavirus: Comparison with SARS-CoV-2


    Yong-Yu Gao 1 , Xiang-Yu Liang 1 , Qian Wang 2 , Shuang Zhang 1 , Han Zhao 1 , Kai Wang 3 , Gui-Xue Hu 4 , William J Liu 5 , Feng-Shan Gao 6



    AffiliationsFree PMC article

    Abstract

    Both feline coronavirus (FCoV) and SARS-CoV-2 are coronaviruses that infect cats and humans, respectively. However, cats have been shown to be susceptible to SARS-CoV-2, and FCoV also had been shown to infect human. To elucidate the relationship between FCoV and SARS-CoV-2, we highlight the main characteristics of the genome, the receptor usage, and the correlation of the receptor-binding domain (RBD) of spike proteins in FCoV and SARS-CoV-2. It is demonstrated that FCoV and SARS-CoV-2 are closely related to the main characteristics of the genome, receptor usage, and RBD of spike proteins with similar furin cleavage sites. In particular, the affinity of the conserved feline angiotensin-converting enzyme 2 (fACE2) receptor to the RBD of SARS-CoV-2 suggests that cats are susceptible to SARS-CoV-2. In addition, cross-species of coronaviruses between cats and humans or other domesticated animals are also discussed. This review sheds light on cats as potential intermediate hosts for SARS-CoV-2 transmission, and cross-species transmission or zoonotic infection of FCoV and SARS-CoV-2 between cats and humans was identified.

    Keywords: Feline coronavirus; Receptor; Receptor-binding domain; SARS-CoV-2; Spike protein.

Working...
X