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Emerg Infect Dis
. 2021 May;27(5).
doi: 10.3201/eid2705.204056.
Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia
Abeer N Alshukairi, Jincun Zhao, Maha A Al-Mozaini, Yanqun Wang, Ashraf Dada, Salim A Baharoon, Sara Alfaraj, Waleed A Ahmed, Mushira A Enani, Fatehi E Elzein, Nazik Eltayeb, Laila Layqah, Aiman El-Saed, Husam A Bahaudden, Abdul Haseeb, Sherif A El-Kafrawy, Ahmed M Hassan, Najlaa A Siddiq, Ibtihaj Alsharif, Isamel Qushmaq, Esam I Azhar, Stanley Perlman, Ziad A Memish
- PMID: 33900908
- DOI: 10.3201/eid2705.204056
Abstract
Understanding the immune response to Middle East respiratory syndrome coronavirus (MERS-CoV) is crucial for disease prevention and vaccine development. We studied the antibody responses in 48 human MERS-CoV infection survivors who had variable disease severity in Saudi Arabia. MERS-CoV-specific neutralizing antibodies were detected for 6 years postinfection.
Keywords: MERS; MERS-CoV; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; Saudi Arabia; antibody responses; coronaviruses; disease severity; humans; longevity; patients; viruses; zoonoses.