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J Infect Dis . Changes in anti-SARS-CoV-2 antibody titers of pooled plasma derived from donors in Japan: a potential tool for mass-immunity evaluation

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  • J Infect Dis . Changes in anti-SARS-CoV-2 antibody titers of pooled plasma derived from donors in Japan: a potential tool for mass-immunity evaluation

    J Infect Dis


    . 2023 May 24;jiad178.
    doi: 10.1093/infdis/jiad178. Online ahead of print. Changes in anti-SARS-CoV-2 antibody titers of pooled plasma derived from donors in Japan: a potential tool for mass-immunity evaluation

    Mikihiro Yunoki 1 2 , Ritsuko Kubota-Koketsu 2 , Teruaki Imada 1 , Kazuhiro Furuyama 3 , Takahiro Sasaki 3 , Shinichi Ohashi 3 , Tatsuo Shioda 2



    AffiliationsAbstract

    The anti-spike (S), anti-nucleocapsid (N), and neutralizing activities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of pooled plasma derived from donors in Japan from January 2021 to April 2022 were evaluated. Anti-S titers and neutralizing activities showed a wave-like trend affected by daily vaccinations and/or the number of reported cases of SARS-CoV-2 infections, whereas anti-N titers remained at negative levels. These results suggest that anti-S and neutralizing titers would fluctuate in pooled plasma in future. Pooled plasma may be potentially used for mass-immunity evaluation, and titer estimation in intravenous immunoglobulin, a derivative of pooled plasma.

    Keywords: COVID-19; IVIG; SARS-CoV-2; anti-N; anti-S; epidemiology; neutralization; vaccination.

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