Brain Behav Immun Health . Monocytosis in the acute phase of SARS-CoV-2 infection predicts the presence of anosognosia for cognitive deficits in the chronic phase

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Brain Behav Immun Health


. 2022 Sep 16;100511.
doi: 10.1016/j.bbih.2022.100511. Online ahead of print.
Monocytosis in the acute phase of SARS-CoV-2 infection predicts the presence of anosognosia for cognitive deficits in the chronic phase


A Nuber-Champier ^{1 2} , P Voruz ^{1 2 3} , I Jacot de Alcântara ^{1 2} , G Breville ² , G Allali ⁴ , P H Lalive ^{2 3} , F Assal ^{2 3} , J A Péron ^{1 2}



Affiliations

• PMID: 36128057
• PMCID: PMC9477785
• DOI: 10.1016/j.bbih.2022.100511

Abstract

Reduced awareness of neuropsychological disorders (i.e., anosognosia) is a striking symptom of post-COVID-19 condition. Some leukocyte markers in the acute phase may predict the presence of anosognosia in the chronic phase, but they have not yet been identified. This study aimed to determine whether patients with anosognosia for their memory deficits in the chronic phase presented specific leukocyte distribution in the acute phase, and if so, whether these leukocyte levels might be predictive of anosognosia. First, we compared the acute immunological data (i.e., white blood cell differentiation count) of 20 patients who displayed anosognosia 6-9 months after being infected with SARS-CoV-2 (230.25 ± 46.65 days) versus 41 patients infected with SARS-Cov-2 who did not develop anosognosia. Second, we performed an ROC analysis to evaluate the predictive value of the leukocyte markers that emerged from this comparison. Blood circulating monocytes (%) in the acute phase of SARS-CoV-2 infection were associated with long-term post-COVID-19 anosognosia. A monocyte percentage of 7.35% of the total number of leukocytes at admission seemed to predict the presence of chronic anosognosia 6-9 months after infection.

Keywords: (AUC), Area under the curve; (CRP), C-reactive protein; (FDR), false discovery rate; (HCoV), human coronavirus; (HIV), human immunodeficiency virus; (HUG), Geneva University Hospitals; (ICU), intensive care unit; (ROC), receiver operating characteristic; (RT-PCR), reverse transcription polymerase chain reaction; (SAE), sepsis-associated encephalopathy; Anosognosia; Cognition; Immunology; Monocytes; Neuropsychology; Post-COVID-19 condition; SARS-CoV-2.