Endocrine . Association of blood glucose level and prognosis of inpatients with coexistent diabetes and COVID-19

[tetano]

Endocrine


. 2021 Oct 30.
doi: 10.1007/s12020-021-02923-7. Online ahead of print.
Association of blood glucose level and prognosis of inpatients with coexistent diabetes and COVID-19


Weiwei Duan ^{# 1 2 3 4} , Liangyu Li ^{# 5 6} , Xuesong Li ^{# 7} , Mengyan Zhu ^{# 5 6} , Lingxiang Wu ^{5 6} , Wei Wu ^{5 6} , Kening Li ^{5 6} , Yuan Liang ^{5 6} , Rong Ding ^{5 6} , Wenhua You ^{5 6} , Ziyu Wang ^{5 6} , Bin Huang ^{5 6} , Min Wu ^{5 6} , Tingting Zhang ^{5 6} , Jie Li ^{5 6} , Yan Li ^{5 6} , Jiaofang Shao ^{5 6} , Changsong Lin ^{5 6} , Pengping Li ^{5 6} , Qianghu Wang ^{5 6 8 9} , Shukui Wang ¹⁰ , Xinyi Xia ^{11 12} , Yu Liu ¹³ , Sali Lyu ^{14 15 16 17}



Affiliations

• PMID: 34716852
• DOI: 10.1007/s12020-021-02923-7

Abstract

Type 2 diabetes (T2D) increases the risk of coronavirus disease (COVID-19). This study investigates the association between glucose control of COVID-19 patients with T2D in first 7 days after hospital admission and prognosis. A total of 252 infected inpatients with T2D in China were included. Well-controlled blood glucose was defined as stable fasting blood glucose (FBG) levels in the range of 3.9-7.8 mmol/L during first 7 days using indicators of average (FBG_A), maximum (FBG_M) or first-time (FBG₁) FBG levels. The primary endpoint was admission to intensive care unit or death. Hazard ratio (HR) of poorly controlled glucose level group compared with well-controlled group were 4.96 (P = 0.021) for FBG_M and 5.55 (P = 0.014) for FBG_A. Well-controlled blood glucose levels in first 7 days could improve the prognosis of COVID-19 inpatients with diabetes.

Keywords: COVID-19; Glucose control; Prognosis analysis; Type 2 diabetes.