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Nat Commun
. 2021 Jul 27;12(1):4543.
doi: 10.1038/s41467-021-24482-1.
The trans-omics landscape of COVID-19
Peng Wu # 1 2 , Dongsheng Chen # 3 , Wencheng Ding # 1 2 , Ping Wu # 1 2 , Hongyan Hou # 4 , Yong Bai # 3 , Yuwen Zhou # 3 5 , Kezhen Li # 1 2 , Shunian Xiang 3 , Panhong Liu 3 , Jia Ju 3 5 , Ensong Guo 1 2 , Jia Liu 1 2 , Bin Yang 1 2 , Junpeng Fan 1 , Liang He 1 , Ziyong Sun 4 , Ling Feng 6 , Jian Wang 7 , Tangchun Wu 8 , Hao Wang 8 , Jin Cheng 9 , Hui Xing 10 , Yifan Meng 11 , Yongsheng Li 12 , Yuanliang Zhang 3 , Hongbo Luo 3 13 , Gang Xie 3 5 , Xianmei Lan 3 , Ye Tao 3 , Jiafeng Li 3 5 , Hao Yuan 3 5 , Kang Huang 3 , Wan Sun 3 , Xiaobo Qian 3 5 , Zhichao Li 3 5 , Mingxi Huang 3 5 , Peiwen Ding 3 5 , Haoyu Wang 3 5 , Jiaying Qiu 3 5 , Feiyue Wang 3 5 , Shiyou Wang 3 5 , Jiacheng Zhu 3 5 , Xiangning Ding 3 5 , Chaochao Chai 3 5 , Langchao Liang 3 5 , Xiaoling Wang 3 5 , Lihua Luo 3 5 , Yuzhe Sun 3 , Ying Yang 3 , Zhenkun Zhuang 3 14 , Tao Li 3 , Lei Tian 3 , Shaoqiao Zhang 15 , Linnan Zhu 3 , Ashley Chang 3 , Lei Chen 16 , Yiquan Wu 17 , Xiaoyan Ma 18 , Fang Chen 3 , Yan Ren 3 , Xun Xu 3 19 , Siqi Liu 3 , Jian Wang 3 20 , Huanming Yang 3 20 , Lin Wang 21 , Chaoyang Sun 22 23 , Ding Ma 24 25 , Xin Jin 26 27 28 , Gang Chen 29 30
Affiliations
- PMID: 34315889
- DOI: 10.1038/s41467-021-24482-1
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.