Glob Health Med . Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan

[tetano]

Glob Health Med


. 2021 Apr 30;3(2):90-94.
doi: 10.35772/ghm.2021.01022.
Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan


Shohei Yamamoto ^{1 2} , Akihito Tanaka ³ , Shinji Kobayashi ³ , Yusuke Oshiro ³ , Mitsuru Ozeki ³ , Kenji Maeda ⁴ , Kouki Matsuda ⁴ , Kengo Miyo ⁵ , Tetsuya Mizoue ¹ , Wataru Sugiura ⁶ , Hiroaki Mitsuya ⁷ , Haruhito Sugiyama ⁸ , Norio Ohmagari ⁹



Affiliations

• PMID: 33937571
• PMCID: PMC8071682
• DOI: 10.35772/ghm.2021.01022

Abstract

We assessed the consistency of seropositive results of three rapid immunoassays (Kits A, B, and C) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to highly accurate serological tests (Abbott and Roche) among healthcare workers in a hospital in Tokyo. The seroprevalence of SARS-CoV-2 immunoglobulin G was 0.41%, 2.36%, and 0.08% using Kits A, B, and C, respectively. Of the 51 samples that were seropositive on any rapid test, all were seronegative on both the Abbott and the Roche assays. Given that the seroprevalence of SARS-CoV-2 immunoglobulin G varied widely according to the choice of rapid test and the rapid test results were inconsistent with the results of highly accurate tests, the diagnostic accuracy of rapid serological tests for SARS-CoV-2 should be assessed before introducing these tests for point-of-care testing or surveillance.

Keywords: COVID-19; SARS-CoV-2; immunoassay; serological tests; seroprevalence.