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Life Sci
. 2021 Jan 14;119019.
doi: 10.1016/j.lfs.2021.119019. Online ahead of print.
Interferon-γ-induced protein 10 (IP-10) and serum amyloid A (SAA) are excellent biomarkers for the prediction of COVID-19 progression and severity
Riham Abdel-Hamid Haroun 1 , Waleed H Osman 2 , Asmaa M Eessa 3
Affiliations
- PMID: 33454365
- DOI: 10.1016/j.lfs.2021.119019
Abstract
Aims: Background: Early diagnosis and appropriate treatment are essential in reducing the morbidity and mortality of COVID-19-infected patients. The current study aimed to measure the levels of serum IP-10 and SAA in positive COVID-19 Egyptian patients to explore their clinical values and significance in discrimination between moderate and severe COVID-19 infection and predicting the severity and prognosis of COVID-19 disease.
Main methods: A total of 150 COVID-19 patients and 50 controls were enrolled into our study. Beside the routine lab work of positive COVID-19 patients; IP-10 and SAA were measured using ELISA kit.
Key findings: Our results revealed that the levels of D-dimer (2.64 ? 3.34), ferritin (494.11 ? 260.96), SAA (171.89 ? 51.96), IP-10 (405.0 ? 85.27), WBCs count (14.38 ? 6.06) and neutrophils count (79.26 ? 5.57) were highly significantly increased in severe to critically severe patients when compared with mild to moderate patients; while lymphocytes count (14.21 ? 5.13) was highly significantly decreased when compared to moderate patients. ROC curve analysis results showed that AUC from high to low was IP-10 ˃ SAA ˃ Ferritin ˃ D-dimer ˃ CRP.
Significance: From these results we can conclude that both IP-10 and SAA could be excellent biomarkers in discrimination between moderate and severe COVID-19 infection and predicting the severity and prognosis of COVID-19 disease.
Keywords: COVID-19; Coronavirus; Cytokine storm syndrome (CSS); Interferon-γ-induced protein 10 (IP-10); Serum amyloid A (SAA).